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8.A.3.3.1 Tyrosine protein kinase of 726 aas and 2 TMSs, Etk (MPA1-C). Probably involved in the regulation of capsular polysaccharide export together with a tyrosine phosphatase, Etp of 148 aas (acc# P0ACZ2) (Peleg et al. 2005; Nadler et al. 2012).
Accession Number:	P38134
Protein Name:	Etk aka B0981
Length:	726
Molecular Weight:	81242.00
Species:	Escherichia coli [83333]
Number of TMSs:	2
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate

Structure:
DIP:	DIP-9526N
RefSeq:	AP_001610.1 NP_415501.1
Entrez Gene ID:	947409
Pfam:	PF02706
BioCyc:	EcoCyc:EG11826-MONOMER ECOL168927:B0981-MONOMER MetaCyc:EG11826-MONOMER
KEGG:	ecj:JW0964 eco:b0981
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005524 F:ATP binding GO:0030234 F:enzyme regulator activity GO:0004713 F:protein tyrosine kinase activity GO:0045227 P:capsule polysaccharide biosynthetic process GO:0009103 P:lipopolysaccharide biosynthetic process
References (7) [1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T.et.al. 8905232 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “The complete nucleotide sequence of the Escherichia coli gene appA reveals significant homology between pH 2.5 acid phosphatase and glucose-1-phosphatase.” Dassa J.et.al. 2168385 [5] “Intrinsic and extrinsic approaches for detecting genes in a bacterial genome.” Borodovsky M.et.al. 7984428 [6] “Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in Gram-negative bacteria.” Vincent C.et.al. 11090276 [7] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996
3CIO

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MTTKNMNTPP GSTQENEIDL LRLVGELWDH RKFIISVTAL FTLIAVAYSL LSTPIYQADT 
61:	LVQVEQKQGN AILSGLSDMI PNSSPESAPE IQLLQSRMIL GKTIAELNLR DIVEQKYFPI 
121:	VGRGWARLTK EKPGELAISW MHIPQLNGQD QQLTLTVGEN GHYTLEGEEF TVNGMVGQRL 
181:	EKDGVALTIA DIKAKPGTQF VLSQRTELEA INALQETFTV SERSKESGML ELTMTGDDPQ 
241:	LITRILNSIA NNYLQQNIAR QAAQDSQSLE FLQRQLPEVR SELDQAEEKL NVYRQQRDSV 
301:	DLNLEAKAVL EQIVNVDNQL NELTFREAEI SQLYKKDHPT YRALLEKRQT LEQERKRLNK 
361:	RVSAMPSTQQ EVLRLSRDVE AGRAVYLQLL NRQQELSISK SSAIGNVRII DPAVTQPQPV 
421:	KPKKALNVVL GFILGLFISV GAVLARAMLR RGVEAPEQLE EHGISVYATI PMSEWLDKRT 
481:	RLRKKNLFSN QQRHRTKNIP FLAVDNPADS AVEAVRALRT SLHFAMMETE NNILMITGAT 
541:	PDSGKTFVSS TLAAVIAQSD QKVLFIDADL RRGYSHNLFT VSNEHGLSEY LAGKDELNKV 
601:	IQHFGKGGFD VITRGQVPPN PSELLMRDRM RQLLEWANDH YDLVIVDTPP MLAVSDAAVV 
661:	GRSVGTSLLV ARFGLNTAKE VSLSMQRLEQ AGVNIKGAIL NGVIKRASTA YSYGYNYYGY 
721:	SYSEKE

8.A.3.3.1
Tyrosine protein kinase of 726 aas and 2 TMSs, Etk (MPA1-C). Probably involved in the regulation of capsular polysaccharide export together with a tyrosine phosphatase, Etp of 148 aas (acc# P0ACZ2) (Peleg et al. 2005; Nadler et al. 2012).

Cross database links:

Gene Ontology

References (7)

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8.A.3.3.1Tyrosine protein kinase of 726 aas and 2 TMSs, Etk (MPA1-C). Probably involved in the regulation of capsular polysaccharide export together with a tyrosine phosphatase, Etp of 148 aas (acc# P0ACZ2) (Peleg et al. 2005; Nadler et al. 2012).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

8.A.3.3.1
Tyrosine protein kinase of 726 aas and 2 TMSs, Etk (MPA1-C). Probably involved in the regulation of capsular polysaccharide export together with a tyrosine phosphatase, Etp of 148 aas (acc# P0ACZ2) (Peleg et al. 2005; Nadler et al. 2012).