Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.3.3.2
Tyrosine protein kinase, Wzc (MPA1-C). The structural basis for the recognition of the bacterial tyrosine kinase Wzc by its cognate tyrosine phosphatase Wzb has been determined (Alphonse et al. 2022).

Accession Number:P76387
Protein Name:Wzc aka B2060
Length:720
Molecular Weight:79343.00
Species:Escherichia coli [83333]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

DIP: DIP-28075N
RefSeq: AP_002660.1    NP_416564.4   
Entrez Gene ID: 946567   
Pfam: PF02706   
BioCyc: EcoCyc:G7105-MONOMER    ECOL168927:B2060-MONOMER    MetaCyc:G7105-MONOMER   
KEGG: ecj:JW2045    eco:b2060   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0030234 F:enzyme regulator activity
GO:0004713 F:protein tyrosine kinase activity
GO:0045227 P:capsule polysaccharide biosynthetic process
GO:0009103 P:lipopolysaccharide biosynthetic process

References (9)

[1] “Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid.”  Stevenson G.et.al.   8759852
[2] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb.”  Vincent C.et.al.   10348860
[6] “Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in Gram-negative bacteria.”  Vincent C.et.al.   11090276
[7] “Tyrosine phosphorylation of protein kinase Wzc from Escherichia coli K12 occurs through a two-step process.”  Grangeasse C.et.al.   11751920
[8] “Autophosphorylation of the Escherichia coli protein kinase Wzc regulates tyrosine phosphorylation of Ugd, a UDP-glucose dehydrogenase.”  Grangeasse C.et.al.   12851388
[9] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
Structure:
3LA6     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MTEKVKQHAA PVTGSDEIDI GRLVGTVIEA RWWVIGITTV FALCAVVYTF FATPIYSADA 
61:	LVQIEQNSGN SLVQDIGSAL ANKPPASDAE IQLIRSRLVL GKTVDDLDLD IAVSKNTFPI 
121:	FGAGWDRLMG RQNETVKVTT FNRPKEMADQ VFTLNVLDNK NYTLSSDGGF SARGQAGQML 
181:	KKEGVTLMVE AIHASPGSEF TVTKYSTLGM INQLQNSLTV TENGKDAGVL SLTYTGEDRE 
241:	QIRDILNSIA RNYQEQNIER KSAEASKSLA FLAQQLPEVR SRLDVAENKL NAFRQDKDSV 
301:	DLPLEAKAVL DSMVNIDAQL NELTFKEAEI SKLYTKVHPA YRTLLEKRQA LEDEKAKLNG 
361:	RVTAMPKTQQ EIVRLTRDVE SGQQVYMQLL NKEQELKITE ASTVGDVRIV DPAITQPGVL 
421:	KPKKGLIILG AIILGLMLSI VGVLLRSLFN RGIESPQVLE EHGISVYASI PLSEWQKARD 
481:	SVKTIKGIKR YKQSQLLAVG NPTDLAIEAI RSLRTSLHFA MMQAQNNVLM MTGVSPSIGK 
541:	TFVCANLAAV ISQTNKRVLL IDCDMRKGYT HELLGTNNVN GLSEILIGQG DITTAAKPTS 
601:	IAKFDLIPRG QVPPNPSELL MSERFAELVN WASKNYDLVL IDTPPILAVT DAAIVGRHVG 
661:	TTLMVARYAV NTLKEVETSL SRFEQNGIPV KGVILNSIFR RASAYQDYGY YEYEYKSDAK