8.A.30.1.4
E3 ubiquitin-protein ligase of 809 aas, RSP5, MDP1, NPI1. RSP5 is a component of a RSP5 ubiquitin ligase
complex which specifies polyubiquitination and intracellular trafficking
of the general amino acid permease GAP1 as well as other cell surface
proteins including FUR4, MAL61, PMA1 and STE2 (Abe and Iida 2003; Pizzirusso and Chang 2004). It plays a role in calcineurin-dependent regulation of endocytosis (Zhu et al. 2020).
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| Accession Number: | P39940 |
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| Protein Name: | E3 ubiquitin-protein ligase RSP5 |
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| Length: | 809 |
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| Molecular Weight: | 91816.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
protein |
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1: MPSSISVKLV AAESLYKRDV FRSPDPFAVL TIDGYQTKST SAAKKTLNPY WNETFKFDDI
61: NENSILTIQV FDQKKFKKKD QGFLGVVNVR VGDVLGHLDE DTATSSGRPR EETITRDLKK
121: SNDGMAVSGR LIVVLSKLPS SSPHSQAPSG HTASSSTNTS STTRTNGHST SSTRNHSTSH
181: PSRGTAQAVE STLQSGTTAA TNTATTSHRS TNSTSSATRQ YSSFEDQYGR LPPGWERRTD
241: NFGRTYYVDH NTRTTTWKRP TLDQTEAERG NQLNANTELE RRQHRGRTLP GGSSDNSSVT
301: VQVGGGSNIP PVNGAAAAAF AATGGTTSGL GELPSGWEQR FTPEGRAYFV DHNTRTTTWV
361: DPRRQQYIRT YGPTNTTIQQ QPVSQLGPLP SGWEMRLTNT ARVYFVDHNT KTTTWDDPRL
421: PSSLDQNVPQ YKRDFRRKVI YFRSQPALRI LPGQCHIKVR RKNIFEDAYQ EIMRQTPEDL
481: KKRLMIKFDG EEGLDYGGVS REFFFLLSHE MFNPFYCLFE YSAYDNYTIQ INPNSGINPE
541: HLNYFKFIGR VVGLGVFHRR FLDAFFVGAL YKMMLRKKVV LQDMEGVDAE VYNSLNWMLE
601: NSIDGVLDLT FSADDERFGE VVTVDLKPDG RNIEVTDGNK KEYVELYTQW RIVDRVQEQF
661: KAFMDGFNEL IPEDLVTVFD ERELELLIGG IAEIDIEDWK KHTDYRGYQE SDEVIQWFWK
721: CVSEWDNEQR ARLLQFTTGT SRIPVNGFKD LQGSDGPRRF TIEKAGEVQQ LPKSHTCFNR
781: VDLPQYVDYD SMKQKLTLAV EETIGFGQE