8.A.30.1.5
E3 ubiquitin-protein ligase Nedd-4 (NEDD4) of 1007 aas. Nedd4 antagonizes Notch signaling by promoting degradation of Notch and Deltex. This function may be important for protecting unstimulated cells from sporadic activation of Notch signaling (Sakata et al. 2004). Drosophila Nedd4 (dNedd4) is a HECT E3 ubiquitin ligase present in two major isoforms:
short (dNedd4S) and long (dNedd4Lo), with the latter containing two
unique regions (N terminus and Middle). Although dNedd4S promotes
neuromuscular synaptogenesis (NMS), dNedd4Lo inhibits it and impairs
larval locomotion (Wasserman et al. 2019). dNedd4Lo destabilizes dAmph in muscles, leading to impaired T-tubule formation and muscle function (Safi et al. 2016).
|
| Accession Number: | Q9VVI3 |
|---|
| Protein Name: | E3 ubiquitin-protein ligase Nedd-4 |
|---|
| Length: | 1007 |
|---|
| Molecular Weight: | 114875.00 |
|---|
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
|---|
| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
|---|
| Substrate |
|
|---|
1: MSARSSGLVA AAALPVPSSS SSVAGGDVPR PPPRRRAASV AGQQQTRQEF GNGYTPRRSL
61: AAVNDSGDSC HLRIVVLTGQ SLAKKDIFGA SDPYVRIDLN TINGDINIDS VLTKTKKKTL
121: NPTWNEEFIF RVKPSEHKLV FQVFDENRLT RDDFLGMVEL TLVNLPTEQE GRTIGEQSYT
181: LRPRRSVGAK SRIKGTLRIY HAFIRETREQ SEPSSGNSDG EWEHVEATNA GETSAQPHPF
241: PTGGHDALPA GWEERQDANG RTYYVNHTAR TTQWDRPTVL NSHSSQSTDD QLASDFQRRF
301: HISVDDTESG RSADSISHNS IEDNNNAAGL AYTPKTAATS SAPPNTPTNN NGILAQIAMQ
361: YRAEEDQDPT VDHTSFVYNS LRHPVAHRQP EISATSLQND LRPVREAPGV PDIAITNPFT
421: RRAAGNMAGG AGWQQERRRQ QMQLHIQQHQ QRQQQQQQNR ILLDVDHRQQ EPQHRGQRHQ
481: QQHRPSNEDT DHTDSHNPSD ISAPSTRRNS EEDNAAVPPM EQNTGGEEEP LPPRWSMQVA
541: PNGRTFFIDH ASRRTTWIDP RNGRASPMPN QTRRVEDDLG PLPEGWEERV HTDGRVFYID
601: HNTRTTQWED PRLSNPNIAG QAVPYSRDYK QKYEYFKSHI RKPTNVPNKF EIRIRRTSIL
661: EDSYRIISSV TKTDLLKTKL WVEFEGETGL DYGGLAREWF YLLSKEMFNP YYGLFEYSAM
721: DNYTLQINNG SGLCNEEHLS YFKFIGRIAG MAVYHGKLLD AFFIRPFYKM MLQKPIDLKD
781: MESVDTEYYN SLMWIKENDP RILELTFCLD EDVFGQKSQH ELKPGGANID VTNENKDEYI
841: KLVIEWRFVA RVKEQMSSFL DGFGSIIPLN LIKIFDEHEL ELLMCGIQNI DVKDWRENTL
901: YKGDYHMNHI IIQWFWRAVL SFSNEMRSRL LQFVTGTSRV PMNGFKELYG SNGPQMFTIE
961: KWGTPNNFPR AHTCFNRLDL PPYEGYLQLK DKLIKAIEGS QGFAGVD