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8.A.33.1.1
The epidermal (psoriasis-associated) fatty acid binding protein, FABP (Wang et al., 2007; Schwenk et al. 2010).  It is a skeletal muscle protein, involved in fatty acid transport, that influences fatty acid oxidation rates (Maunder et al. 2023).  Upregulating FcRn inhibits ferroptosis to alleviate lesional skin in psoriasis (Qian et al. 2024).  The neonatal Fc receptor (FcRn) plays a crucial role in the development of autoimmune diseases (Schwenk et al. 2010).  It is a skeletal muscle protein, involved in fatty acid transport, that influences fatty acid oxidation rates (Maunder et al. 2023).  Upregulating FcRn inhibits ferroptosis to alleviate lesional skin in psoriasis (Qian et al. 2024).  The neonatal Fc receptor (FcRn) plays a crucial role in the development of autoimmune diseases (Qian et al. 2024).

Accession Number:Q01469
Protein Name:Fatty acid-binding protein, epidermal aka FABP
Length:135
Molecular Weight:15164.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate

Cross database links:

RefSeq: NP_001435.1   
Entrez Gene ID: 2171   
Pfam: PF00061   
OMIM: 605168  gene
KEGG: hsa:2171   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0005504 F:fatty acid binding
GO:0005515 F:protein binding
GO:0005215 F:transporter activity
GO:0008544 P:epidermis development
GO:0006629 P:lipid metabolic process
GO:0006810 P:transport

References (11)

[1] “Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins.”  Madsen P.S.et.al.   1512466
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.”  Gevaert K.et.al.   12665801
[5] “Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.”  Rasmussen H.H.et.al.   1286667
[6] “Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro.”  Siegenthaler G.et.al.   8092987
[7] “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.”  Rush J.et.al.   15592455
[8] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[9] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[10] “Expression, purification and crystal structure determination of recombinant human epidermal-type fatty acid-binding protein.”  Hohoff C.et.al.   10493790
[11] “Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP).”  Gutierrez-Gonzalez L.H.et.al.   12049637
Structure:
1B56   1JJJ   4AZM   4AZR   4LKP   4LKT   5HZ5   5UR9     

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FASTA formatted sequence 
1:	MATVQQLEGR WRLVDSKGFD EYMKELGVGI ALRKMGAMAK PDCIITCDGK NLTIKTESTL 
61:	KTTQFSCTLG EKFEETTADG RKTQTVCNFT DGALVQHQEW DGKESTITRK LKDGKLVVEC 
121:	VMNNVTCTRI YEKVE