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8.A.40.1.2
Tetraspanin-7 (Tspan-7; TALLA1; MXS1; TM4SF2) (Hemler, 2005). Defects in humans result in mental retardation, called x-linked type 58 (MRX58) (Hemler, 2005).  Contains sphingolipid binding motifs (Björkholm et al. 2014).  Tspan-7 is the target of autoantibodies and type I diabetes (McLaughlin et al. 2016). Tspan7 is an islet autoantigen involved in autoimmune type 1 diabetes and regulates beta-cell L-type Ca2+ channel activity (McLaughlin et al. 2022). It thereby regulates Ca2+-dependent exocytosis in beta-cells (McLaughlin et al. 2022).

Accession Number:P41732
Protein Name:Tetraspanin-7
Length:249
Molecular Weight:27574.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 7102   
Pfam: PF00335   
KEGG: hsa:7102   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0044419 P:interspecies interaction between organisms

References (6)

[1] “Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily.”  Emi N.et.al.   8420826
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily.”  Takagi S.et.al.   7768645
[4] “A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation.”  Zemni R.et.al.   10655063
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein.”  Wang L.et.al.   20630051

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL IAENSTNAPY 
61:	VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL AELVAGISGF VFRHEIKDTF 
121:	LRTYTDAMQT YNGNDERSRA VDHVQRSLSC CGVQNYTNWS TSPYFLEHGI PPSCCMNETD 
181:	CNPQDLHNLT VAATKVNQKG CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF 
241:	ITANQYEMV