8.A.40.1.21
Tetraspanin14 (Tspan14) of 270 aas and 4 TMSs. Interacts with disintegrin and metalloprotease 10 (ADAM10), a ubiquitously expressed transmembranemetalloprotease that cleaves the extracellular regions from its transmembrane substrates (Noy et al. 2016). ADAM10 is essential for embryonic development and is implicated in cancer, Alzheimer's disease, and inflammatory diseases. The tetraspanins are a superfamily of 33 four-transmembrane proteins in mammals, of which the TspanC8 subgroup (Tspan5, 10, 14, 15, 17, and 33) promote ADAM10 intracellular trafficking and enzymatic maturation (Jouannet et al. 2016).