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8.A.40.1.23 Tetraspannin, Tspan18 of 248 aas and 4 TMSs in a 3 + 1 arrangement. It is a regulator of Orai1, a store-operated Ca²⁺ channels in the plasma membrane which is critical to cell function. Orai1 loss causes severe immunodeficiency and developmental defects (Noy et al. 2018).
Accession Number:	Q96SJ8
Protein Name:	Tetraspanin-18
Length:	248
Molecular Weight:	27710.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	4
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate

UniProt (Universal Protein Resource)
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FASTA formatted sequence

1:	MEGDCLSCMK YLMFVFNFFI FLGGACLLAI GIWVMVDPTG FREIVAANPL LLTGAYILLA 
61:	MGGLLFLLGF LGCCGAVREN KCLLLFFFLF ILIIFLAELS AAILAFIFRE NLTREFFTKE 
121:	LTKHYQGNND TDVFSATWNS VMITFGCCGV NGPEDFKFAS VFRLLTLDSE EVPEACCRRE 
181:	PQSRDGVLLS REECLLGRSL FLNKQGCYTV ILNTFETYVY LAGALAIGVL AIELFAMIFA 
241:	MCLFRGIQ

8.A.40.1.23
Tetraspannin, Tspan18 of 248 aas and 4 TMSs in a 3 + 1 arrangement. It is a regulator of Orai1, a store-operated Ca²⁺ channels in the plasma membrane which is critical to cell function. Orai1 loss causes severe immunodeficiency and developmental defects (Noy et al. 2018).

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8.A.40.1.23Tetraspannin, Tspan18 of 248 aas and 4 TMSs in a 3 + 1 arrangement. It is a regulator of Orai1, a store-operated Ca2+ channels in the plasma membrane which is critical to cell function. Orai1 loss causes severe immunodeficiency and developmental defects (Noy et al. 2018).

Cross database links:

External Searches:

Analyze:

8.A.40.1.23
Tetraspannin, Tspan18 of 248 aas and 4 TMSs in a 3 + 1 arrangement. It is a regulator of Orai1, a store-operated Ca²⁺ channels in the plasma membrane which is critical to cell function. Orai1 loss causes severe immunodeficiency and developmental defects (Noy et al. 2018).