8.A.40.1.8
Tretraspanin-13. TSPAN-13 (NET6, TM4F13, UNC260,PRO296) specifically
modulates the efficiency of coupling between voltage sensor activation and pore opening of the
CaV2.2 α-subunit channel and accelerates the voltage-dependent activation and inactivation of the Ba2+ current
through CaV2.2. TSPAN-13 may regulate CaV2.2 Ca2+ channel activity in
defined synaptic membrane compartments and thereby influences transmitter release (Mallmann et al. 2013; Lacinova et al. 2020). The human ortholog is 96% identical to the mouse protein.
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| Accession Number: | Q9D8C2 |
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| Protein Name: | Tetraspanin-13 |
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| Length: | 204 |
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| Molecular Weight: | 22219.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MVCGGFSCSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI AVGIFLFLIA
61: LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN REQQGQLLEV GWNNTASARN
121: DIQRNLNCCG FRSYNPNDTC PASCAKSTQK CSSCAPIIGE YAGEVLRFVG GIGLFFSFTE
181: ILGVWLTYRY RNQKDPRANP SAFL