8.A.40.1.9
Tetraspanin 29 (TSPAN29; CD9 antigen; GIG2; leucocyte antigen MIC3) of 228 aas and 4 TMSs.  Plays a role in mast cell chemotaxis (Hálová et al. 2013).  Also required for egg-sperm interactions during cell-cell fusion (Sabetian et al. 2014). It is associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (Ikeyama et al. 1993, Higginbottom et al. 2003, Nakazawa et al. 2008). In myoblasts, it associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, it associates with CD81 and beta-1 and beta-2 integrins, to prevent macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (Takeda et al. 2003).