8.A.40.7.1
Uroplakin 1a (UPK1A or TSPAN21) of 258 aas and 4 TMSs in a 3 + 1 arrangement. Component of the asymmetric unit membrane
(AUM), a highly specialized biomembrane elaborated by terminally
differentiated urothelial cells. May play a role in normal
bladder epithelial physiology, possibly in regulating membrane
permeability of superficial umbrella cells (Chicote et al. 2017).
|
| Accession Number: | O00322 |
|---|
| Protein Name: | Uroplakin-1a |
|---|
| Length: | 258 |
|---|
| Molecular Weight: | 28879.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 4 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MASAAAAEAE KGSPVVVGLL VVGNIIILLS GLSLFAETIW VTADQYRVYP LMGVSGKDDV
61: FAGAWIAIFC GFSFFMVASF GVGAALCRRR SMVLTYLVLM LIVYIFECAS CITSYTHRDY
121: MVSNPSLITK QMLTFYSADT DQGQELTRLW DRVMIEQECC GTSGPMDWVN FTSAFRAATP
181: EVVFPWPPLC CRRTGNFIPL NEEGCRLGHM DYLFTKGCFE HIGHAIDSYT WGISWFGFAI
241: LMWTLPVMLI AMYFYTML