8.A.43.1.1
The heme sequestration protein, Shr (Ouattara et al., 2010) (feeds iron into the Shp/SiaABC (HtsABC) ABC uptake system (3.A.1.14.10)). The two NEAT domains are not equivalent (Ouattara et al. 2013).
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| Accession Number: | B0LFQ8 |
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| Protein Name: | Heme-binding protein Shr |
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| Length: | 1275 |
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| Molecular Weight: | 142704.00 |
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| Species: | Streptococcus pyogenes [1314] |
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| Number of TMSs: | 1 |
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| Substrate |
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| Pfam: |
PF07550
PF00560
PF05031
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[1] “The surface protein Shr of Streptococcus pyogenes binds heme and transfers it to the streptococcal heme-binding protein Shp.” Zhu H. et.al. 18215300
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1: MKKISKCAFV AISALVLIQA TQTVKSQEPL VQSQLVTTVA LTQDNRLLVE EIGPYASQSA
61: GKEYYKHIEK IIVDNDVYEK SLEGERTFDI NYQGIKINAD LIKDGKHELT IVNKKDGDIL
121: ITFIKKGDKV TFISAQKLGT TDHQDSLKKD VLSDKTVPQN QGTQKVVKSG KNTANLSLIT
181: KLSQEDGAIL FPEIDRYSDN KQIKALTQQI TKVTVNGTVY KDLISDSVKD TNGWVSNMTG
241: LHLGTKAFKD GENTIVISSK GFEDVTITVT KKDGQIHFVS AKQKQHVTAE DRQSTKLDVT
301: TLEKAIKEAD AIIAKESNKD AVKDLAEKLQ VIKDSYKEIK DSKLLADTHR LLKDTIESYQ
361: AGEVSINNLT EGTYTLNFKA NKENSEESSM LQGAFDKRAK LVVKADGTME ISMLNTALGQ
421: FLIDFSIESK GTYPAAVRKQ VGQKDINGSY IRSEFTMPID DLDKLHKGAV LVSAMGGQES
481: DLNHYDKYTK LDMTFSKTVT KGWSGYQVET DDKEKGVGTE RLEKVLVKLG KDLDGDGKLS
541: KTELEQIRGE LRLDHYELTD ISLLKHAKNI TELHLDGNQI TEIPKELFSQ MKQLRFLNLR
601: SNHLTYLDKD TFKSNAQLRE LYLSSNFIHS LEGGLFQSLH HLEQLDLSKN RIGRLCDNPF
661: EGLSRLTSLG FAENSLEEIP EKALEPLTSL NFIDLSQNNL ALLPKTIEKL RALSTIVASR
721: NHITRIDNIS FKNLPKLSVL DLSTNEISNL PNGIFKQNNQ LTKLDFFNNL LTQVEESVFP
781: DVETLNLDVK FNQIKSVSPK VRALIGQHKL TPQKHIAKLE ASLDGEKIKY HQAFSLLDLY
841: YWEQKTNSAI DKELVSVEEY QQLLQEKGSD TVSLLNDMQV DWSIVIQLQK KASNGQYVTV
901: DEKLLSNDPK DDLTGEFSLK DPGTYRIRKA LITKKFATQK EHIYLTSNDI LVAKGPHSHQ
961: KDLVENGLRA LNQKQLRDGI YYLNASMLKT DLASESMSNK AINHRVTLVV KKGVSYLEVE
1021: FRGIKVGKML GYLGELSYFV DGYQRDLAGK PVGRTKKAEV VSYFTDVTGL PLADRYGKNY
1081: PKVLRMKLIE QAKKDGLVPL QVFVPIMDAI SKGSGLQTVF MRLDWASLTT EKAKVVKETN
1141: NPQENSHLTS TDQLKGPQNR QQEKTPTSPP SAATGIANLT DLLAKKATGQ STQETSKTDD
1201: TDKAEKLKQL VRDHQTSIEG KTAKDTKTKK SDKKHRSNQQ SNGEESSSRY HLIAGLSSFM
1261: IVALGFIIGR KTLFK