8.A.43.1.21
Leucine-rich repeats and immunoglobulin-like domains protein 1, LRIG1, of 1093 aas. It consists of a signal peptide, 15 tandem leucine-rich repeats with cysteine-rich N- and C-flanking domains, three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail (Guo et al. 2004). It acts as a feedback negative regulator of signaling
by receptor tyrosine kinases, through a mechanism that involves
enhancement of receptor ubiquitination and accelerated intracellular
degradation (Gur et al. 2004). The functions of LRIG proteins in glioma have been reviewed (Mao et al. 2017).
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| Accession Number: | Q96JA1 |
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| Protein Name: | Leucine-rich repeats and immunoglobulin-like domains protein 1 |
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| Length: | 1093 |
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| Molecular Weight: | 119113.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MARPVRGGLG APRRSPCLLL LWLLLLRLEP VTAAAGPRAP CAAACTCAGD SLDCGGRGLA
61: ALPGDLPSWT RSLNLSYNKL SEIDPAGFED LPNLQEVYLN NNELTAVPSL GAASSHVVSL
121: FLQHNKIRSV EGSQLKAYLS LEVLDLSLNN ITEVRNTCFP HGPPIKELNL AGNRIGTLEL
181: GAFDGLSRSL LTLRLSKNRI TQLPVRAFKL PRLTQLDLNR NRIRLIEGLT FQGLNSLEVL
241: KLQRNNISKL TDGAFWGLSK MHVLHLEYNS LVEVNSGSLY GLTALHQLHL SNNSIARIHR
301: KGWSFCQKLH ELVLSFNNLT RLDEESLAEL SSLSVLRLSH NSISHIAEGA FKGLRSLRVL
361: DLDHNEISGT IEDTSGAFSG LDSLSKLTLF GNKIKSVAKR AFSGLEGLEH LNLGGNAIRS
421: VQFDAFVKMK NLKELHISSD SFLCDCQLKW LPPWLIGRML QAFVTATCAH PESLKGQSIF
481: SVPPESFVCD DFLKPQIITQ PETTMAMVGK DIRFTCSAAS SSSSPMTFAW KKDNEVLTNA
541: DMENFVHVHA QDGEVMEYTT ILHLRQVTFG HEGRYQCVIT NHFGSTYSHK ARLTVNVLPS
601: FTKTPHDITI RTTTMARLEC AATGHPNPQI AWQKDGGTDF PAARERRMHV MPDDDVFFIT
661: DVKIDDAGVY SCTAQNSAGS ISANATLTVL ETPSLVVPLE DRVVSVGETV ALQCKATGNP
721: PPRITWFKGD RPLSLTERHH LTPDNQLLVV QNVVAEDAGR YTCEMSNTLG TERAHSQLSV
781: LPAAGCRKDG TTVGIFTIAV VSSIVLTSLV WVCIIYQTRK KSEEYSVTNT DETVVPPDVP
841: SYLSSQGTLS DRQETVVRTE GGPQANGHIE SNGVCPRDAS HFPEPDTHSV ACRQPKLCAG
901: SAYHKEPWKA MEKAEGTPGP HKMEHGGRVV CSDCNTEVDC YSRGQAFHPQ PVSRDSAQPS
961: APNGPEPGGS DQEHSPHHQC SRTAAGSCPE CQGSLYPSNH DRMLTAVKKK PMASLDGKGD
1021: SSWTLARLYH PDSTELQPAS SLTSGSPERA EAQYLLVSNG HLPKACDASP ESTPLTGQLP
1081: GKQRVPLLLA PKS