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8.A.43.1.22
Toll/interleukin-1 receptor domain-containing adapter protein, TIRAP or MAL, of 221 aas. It is an adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. It acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B and resulting in cytokine secretion and the inflammatory response (Nagpal et al. 2009). Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular TIR domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors are present in mammals (McGettrick and O'Neill 2004).  

Accession Number:P58753
Protein Name:Toll/interleukin-1 receptor domain-containing adapter protein
Length:221
Molecular Weight:23883.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate

Cross database links:

Structure:
2NDH   2Y92   3UB2   3UB3   3UB4   4FZ5   4LQD   5T7Q   5UZB      [...more]

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASSTSLPAP GSRPKKPLGK MADWFRQTLL KKPKKRPNSP ESTSSDASQP TSQDSPLPPS 
61:	LSSVTSPSLP PTHASDSGSS RWSKDYDVCV CHSEEDLVAA QDLVSYLEGS TASLRCFLQL 
121:	RDATPGGAIV SELCQALSSS HCRVLLITPG FLQDPWCKYQ MLQALTEAPG AEGCTIPLLS 
181:	GLSRAAYPPE LRFMYYVDGR GPDGGFRQVK EAVMRYLQTL S