8.A.47.1.4
Supressor of lurcher protein, Sol-1, of 594 aas and 2 TMSs, one N-terminal and one C-terminal. Sol1 is an accessory protein required for
glutamate-gated currents that participate in the gating of non-NMDA
(N-methyl-D-aspartate) ionotropic glutamate receptors such as Glr-1. It is predicted to contain four extracellular
beta-barrel-forming domains known as CUB domains. SOL-1 and GLR-1 colocalize to the cell surface and can be co-immunoprecipitated. By
recording from neurons expressing GLR-1, SOL-1 is selectively required for glutamate-gated
currents (Zheng et al. 2004) and regulates desensitization (Walker et al. 2006).
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| Accession Number: | Q93212 |
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| Protein Name: | Suppressor of lurcher protein 1 |
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| Length: | 594 |
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| Molecular Weight: | 68233.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell junction1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MCRRAEDLVL LLIPILFGYF SHASEHECKC VLFNVTSGNF HSPEFPAPLE GVPCLFYHFQ
61: APPDHIIRLT FDVFQLPPRI GVCSSSIMLF DHSTDGLIEF GERADFEFCG KEISSGRQFF
121: SKDQHFLLQI SSGKESSRGF RGSFLAIPKK NFTSDAVEMA ECSYRVEKQK AIIYSPDYPY
181: YYPSKVNCTY HIPQRKGFQI VVNSIVMDIG RDAILQIFES VEGKFEKRLI EMVTSVQKSI
241: YVSSTSSLLI YFSAGNNDVE RAVGFVIELQ YSNAVWSQSP ETASECQLNI NSENFKEGQL
301: SSDKIGRFTS SSLPTKCQIV LQGYPNEKIS VKFTHFNLYV PDNKNVTKRC TEVDNLSADV
361: RVGSRLSRID EWCGKRAPPN LMSSSNLLQL EYNTKSSKAI RESTNDDIGF RLDYKFHTDW
421: NMGNMKAKVD KKKECRFSFN SSEHTNGKLW SANYPGLYPR NLYCEYIFHG RNDQVVHIHF
481: EYFDIEGFNQ CDETTQSDYI LFSNYQTHDR TNRRFCGKTA PKGPILSESN YFRMIFSTND
541: IFDATGFYAH YQFITQEKSQ ISRVKLTISS SQTPFSSFFL VILLFTFRYI ANIF