| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.5.1.1 | K+ channel β1a chain. Functions with Kv1.2 (Kvα1;KCNA2; TC# 1.A.1.2.10) to promote fast inactivation (Peters et al. 2009). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (Accili et al. 1998). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels Accelerates the closure of heteromeric channels formed by KCNA1, KCNA2, KCNA4, KCNA5 and KCNA6. Binds NADPH as is required for efficient down-regulation of potassium channel activity (Tipparaju et al. 2007). The protein has NADPH-dependent aldoketoreductase activity, and oxidation of the bound NADPH decreases N-type inactivation of channel activity. | Eukaryota |
Metazoa, Chordata | K+ channel subunit β1a of Homo sapiens (Q14722) |
|
8.A.5.1.2 | The hyperkinetic (Hk) protein | Eukaryota |
Metazoa, Arthropoda | Hk of Drosophila melanogaster (Q24052) |
|
8.A.5.1.3 | Chain A, β-subunit (x-ray structure available for this protein) | Eukaryota |
Metazoa, Chordata | β1a of Rattus norvegicus (P63144) |
|
8.A.5.1.4 | General stress protein 69, GSP69. There is no evidence that this protein functions to regulate a transport system in bacteria. | Bacteria |
Bacillota | GSP69 of Bacillus subtilis |
|
8.A.5.1.5 | Aldo/keto (NADH) reductase of 346 aas, Tas. There is no evidence that this protein functions to regulate a transport system in bacteria. | Bacteria |
Pseudomonadota | Tas of E. coli |
|
8.A.5.1.6 | Uncharacterized oxidoreductase of 342 aas, YajO. There is no evidence that this protein functions to regulate a transport system in bacteria. | Bacteria |
Pseudomonadota | YajO of E. coli |
|
8.A.5.1.7 | Oxidoreductase, YdhF, of 298 aas and 0 TMSs. Not known to be involved in transport. | Bacteria |
Pseudomonadota | YdhF of E. coli |