| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.5.1.1 | K+ channel β1a chain. Functions with Kv1.2 (Kvα1;KCNA2; TC# 1.A.1.2.10) to promote fast inactivation (Peters et al. 2009). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (Accili et al. 1998). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels Accelerates the closure of heteromeric channels formed by KCNA1, KCNA2, KCNA4, KCNA5 and KCNA6. Binds NADPH as is required for efficient down-regulation of potassium channel activity (Tipparaju et al. 2007). The protein has NADPH-dependent aldoketoreductase activity, and oxidation of the bound NADPH decreases N-type inactivation of channel activity. | Eukaryota |
Metazoa, Chordata | K+ channel subunit β1a of Homo sapiens (Q14722) |
|
8.A.5.1.2 | The hyperkinetic (Hk) protein | Eukaryota |
Metazoa, Arthropoda | Hk of Drosophila melanogaster (Q24052) |
|
8.A.5.1.3 | Chain A, β-subunit of 353 aas and possibly 3 C-terminal TMSs. The x-ray structure is available for this protein. The Kcnab2 ortholog in Danio rerio (Zebrafish) (Brachdanio rerio) (XP_009304567.1) is 85% identical to the rat homolog. It belongs to the shaker potassium channel beta subunit family. Genome analysis revealed that genetic structure is influenced by a variety of factors including salinity gradients, habitat distance, and ocean currents (Wang et al. 2024). | Eukaryota |
Metazoa, Chordata | β1a of Rattus norvegicus (P63144) |
|
8.A.5.1.4 | General stress protein 69, GSP69. There is no evidence that this protein functions to regulate a transport system in bacteria. | Bacteria |
Bacillota | GSP69 of Bacillus subtilis |
|
8.A.5.1.5 | Aldo/keto (NADH) reductase of 346 aas, Tas. There is no evidence that this protein functions to regulate a transport system in bacteria. | Bacteria |
Pseudomonadota | Tas of E. coli |
|
8.A.5.1.6 | Uncharacterized oxidoreductase of 342 aas, YajO. There is no evidence that this protein functions to regulate a transport system in bacteria. | Bacteria |
Pseudomonadota | YajO of E. coli |
|
8.A.5.1.7 | Oxidoreductase, YdhF, of 298 aas and 0 TMSs. Not known to be involved in transport. | Bacteria |
Pseudomonadota | YdhF of E. coli |