8.A.52.2.1
E3 ubiquitin-protein ligase, parkin (PRKN), of 465 aas and 0 - 1 TMSs. Parkin regulates neuronal CaV1.3 channel functional expression (Grimaldo et al. 2022). It is a target of mutations in parkinson's disease. Silibinin alleviates ferroptosis of rat islet β
cell INS-1 induced by treatment with palmitic acid and high glucose
through enhancing PINK1/parkin-mediated mitophagy (Du et al. 2023).
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| Accession Number: | O60260 |
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| Protein Name: | E3 ubiquitin-protein ligase parkin |
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| Length: | 465 |
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| Molecular Weight: | 51641.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD
61: LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA
121: VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP
181: SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT
241: CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE
301: LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC
361: GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR
421: CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV