| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.54.1.1 | Integrin α-1 (AITGA1) or CD49 of 1179 aas and 2 TMSs (N- and C-termini). Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Plays a role in sperm-egg fusion as a receptor, but not as the fusogen (Sabetian et al. 2014). | Eukaryota |
Metazoa, Chordata | CD49 of Homo sapiens |
|
8.A.54.1.2 | Integrin α-6 of 1130 aas. Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (Pawar et al. 2007). | Eukaryota |
Metazoa, Chordata | ITGAE of Homo sapiens |
|
8.A.54.1.3 | Cochlin of 550 aas and 1 N-terminal TMS, possibly with more TMSs in the rest of the protein. Shows similarity with a protein of TC# 2.A.74.1.6 as well as 8.A.54.1.1. binds to ZCTL2 (SLC44A2), a putative choline transporter (TC# 2.A.92.1.2) (Kommareddi et al. 2007). It may be associated with Meniere's Disease (Lopez-Escamez et al. 2018). | Eukaryota |
Metazoa, Chordata | Cochlin of Homo sapiens |
|
8.A.54.1.4 | Integrin alpha5, ITGA5, of 1048 aas. Functions with beta subunits such as beta1 (TC# 9.B.87.1.8) (Häussinger and Kordes 2017). It is a potential biomarker of head and neck squamous cell carcinoma (Zou et al. 2019). Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins (Short et al. 2005). | Eukaryota |
Metazoa, Chordata | Integrin α5 of Homo sapiens |
|
8.A.54.1.5 | Integrin alpha7 of 1181 aas and 2 TMSs, N- and C-terminal. Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers (Tran et al. 2007). Signaling via this protein regulates connexin 43, M-cadherin, and myoblast fusion (McClure et al. 2019).
| Eukaryota |
Metazoa, Chordata | Integrin α7 of Homo sapiens |
|
8.A.54.1.6 | Transmembrane integrin α-L, ITGAL, of 1170 aas and 2 TMSs, N- and C-terminal. These proteins may play a role in amoeboid swimming, propelled by molecular paddling in lymphocytes (Aoun et al. 2020). Leukocytes can swim, and efficient propulsion is by a rearward and inhomogeneous treadmilling of the cell external membrane. Thus, a molecular paddling by transmembrane proteins linked to and advected by the actin cortex is responsible for motility, whereas freely diffusing transmembrane proteins hinder swimming. Continuous paddling is enabled by a combination of external treadmilling and selective recycling by internal vesicular transport of cortex-bound transmembrane proteins (Aoun et al. 2020). | Eukaryota |
Metazoa, Chordata | ITGAL of Homo sapiens |
|
8.A.54.1.7 | Integrin alpha-11, α-11, α11, of 1188 aas and 4 TMSs, one N-terminal, two close to each other in a central location in the protein, and one C-terminal. It is a receptor for collagen (Gullberg and Lundgren-Akerlund 2002). Mechanical tension and integrin beta-1 regulate fibroblast functions (Eckes et al. 2006). Cells contain at least two types of collagen receptors: integrins and discoidin domain receptors (DDRs) (Yeh et al. 2012). | Eukaryota |
Metazoa, Chordata | Integrin α11 of Homo sapiens |
|
8.A.54.1.8 | Alpha 5 integrin of 1049 aas and 2 TMSs, N- and C-terminal. It forms a dimer with the Beta1 integrin of 200 aas and 0 TMSs. This essential heterodimeric transmembrane protein mediates the communication between the extracellular matrix and the cytosolic cytoskeleton in processes of cell adhesion and migration (Dransart et al. 2022). | Eukaryota |
Metazoa, Chordata | α5/β1 integrin of Homo sapiens α5 integrin, P08640 β1 integrin, O14713 |