8.A.55.1.1
IZUMO sperm-egg fusion protein 1of 350 aas and 2 TMSs (N- and C-termini). Essential
sperm cell-surface protein required for fertilization by acting as a
ligand for the IZUMO1R/JUNO receptor on the egg. The IZUMO1:IZUMO1R/JUNO
interaction is a necessary adhesion event between sperm and egg that is
required for fertilization but is not sufficient for cell fusion (Inoue et al. 2013). The
ligand-receptor interaction probably does not act as a membrane
'fusogen' (Klinovska et al. 2014).
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| Accession Number: | Q8IYV9 |
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| Protein Name: | Izumo sperm-egg fusion protein 1 |
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| Length: | 350 |
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| Molecular Weight: | 38930.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MGPHFTLLCA ALAGCLLPAE GCVICDPSVV LALKSLEKDY LPGHLDAKHH KAMMERVENA
61: VKDFQELSLN EDAYMGVVDE ATLQKGSWSL LKDLKRITDS DVKGDLFVKE LFWMLHLQKE
121: TFATYVARFQ KEAYCPNKCG VMLQTLIWCK NCKKEVHACR KSYDCGERNV EVPQMEDMIL
181: DCELNWHQAS EGLTDYSFYR VWGNNTETLV SKGKEATLTK PMVGPEDAGS YRCELGSVNS
241: SPATIINFHV TVLPKMIKEE KPSPNIVTPG EATTESSISL QPLQPEKMLA SRLLGLLICG
301: SLALITGLTF AIFRRRKVID FIKSSLFGLG SGAAEQTQVP KEKATDSRQQ