8.A.56.1.1
Wntless, Evenness interrupted or Sprinter (Wls; Evi; Srt) protein of 594 aas and 9 TMSs (Bartscherer et al. 2006). Wls directs wg and wnt secretion (Franch-Marro et al. 2008; Hausmann et al. 2007). Wls forms a complex with Procupine (PORCN), and the two proteins have dissimilar functions in the overall secretion process with Wls being the only one of these proteins to function directly in sercetion (Galli et al. 2016).
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| Accession Number: | Q95ST2 |
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| Protein Name: | Protein wntless |
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| Length: | 594 |
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| Molecular Weight: | 67890.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Cell junction1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSGTILENLS GRKLSILVAT LLLCQVLCFL LGGLYAPLPA GHVTVLGSLC REDHARQNDT
61: SFLLYSRGAG ACIPVTREEV EQDSTKMANE LVHVFQMPLP RDLRDLDYSR WQQNLIGVLQ
121: VEFGYDSSSE LREPPRELQL TIDMRLAYRN KGDPDNGWKL YAHGVEHRYL DCVTSHVGPT
181: ETLYSCDMIP LFELGALHHS FYLLNLRFPL DTPSQMNLQF GHMHDLTLTA IHQNGGFTQI
241: WLLLKTMLFP FVVGIMIWFW RRVHLLQRSP ALLEYMLIYL GAALTFLNLP LEYLSLVYEM
301: PYMLLLSDIR QGIFYAMLLT FWLVFAGEHM LIQDAPNKST IRSRYWKHLS AVVVGCISLF
361: VFDICERGVQ LRNPFYSIWT TPLGAKVAMT FIVLAGVSAA IYFLFLCYMI WKVFRNIGDK
421: RTSLPSMSQA RRLHYEVPLD QKVEDWAGIV YFYTKAFFFQ LHKANESKGL IYRFKFLMLA
481: TLVCAALTVA GFIMGQMAEG QWDWNDNVAI QPTSAFLTGV YGMWNIYIFA LLILYAPSHK
541: QWPTMHHSDE TTQSNENIVA SAASEEIEFS HLPSDSNPSE ISSLTSFTRK VAFD