8.A.56.1.2
Wntless (Wls) protein of 541 aas and 8 TMSs in a 1 + 7 TMS arrangement. Regulates
Wnt protein sorting and secretion in a feedback regulatory mechanism.
This reciprocal interaction plays a key role in the regulation of
expression, subcellular location, binding and organelle-specific
association of Wnt proteins (Xiao et al. 2015).
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| Accession Number: | Q5T9L3 |
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| Protein Name: | Protein wntless homolog |
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| Length: | 541 |
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| Molecular Weight: | 62253.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MAGAIIENMS TKKLCIVGGI LLVFQIIAFL VGGLIAPGPT TAVSYMSVKC VDARKNHHKT
61: KWFVPWGPNH CDKIRDIEEA IPREIEANDI VFSVHIPLPH MEMSPWFQFM LFILQLDIAF
121: KLNNQIRENA EVSMDVSLAY RDDAFAEWTE MAHERVPRKL KCTFTSPKTP EHEGRYYECD
181: VLPFMEIGSV AHKFYLLNIR LPVNEKKKIN VGIGEIKDIR LVGIHQNGGF TKVWFAMKTF
241: LTPSIFIIMV WYWRRITMMS RPPVLLEKVI FALGISMTFI NIPVEWFSIG FDWTWMLLFG
301: DIRQGIFYAM LLSFWIIFCG EHMMDQHERN HIAGYWKQVG PIAVGSFCLF IFDMCERGVQ
361: LTNPFYSIWT TDIGTELAMA FIIVAGICLC LYFLFLCFMV FQVFRNISGK QSSLPAMSKV
421: RRLHYEGLIF RFKFLMLITL ACAAMTVIFF IVSQVTEGHW KWGGVTVQVN SAFFTGIYGM
481: WNLYVFALMF LYAPSHKNYG EDQSNGDLGV HSGEELQLTT TITHVDGPTE IYKLTRKEAQ
541: E