8.A.6.1.2
Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein, Lpd-1 or LPD3, of 4018 aas and at least one N-terminal TMS, but several additional potential TMSs. It is a tube-forming lipid transport protein which provides
phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor
synthesis in the endoplasmic reticulum. It also plays a role in
endosomal trafficking and endosome recycling, and is involved in the actin
cytoskeleton and cilia structural dynamics (Kane et al. 2019). It acts as a regulator of phagocytosis (Jeng et al. 2019). The structural basis of bulk lipid transfer by bridge-like lipid transfer protein LPD-3 in C. elegans has been solved (Kang et al. 2024).
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| Accession Number: | NP_001300464 |
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| Protein Name: | NP_001300464.1 Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans] |
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| Length: | 4019 |
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| Molecular Weight: | |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 1 |
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| Substrate |
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1: MSDFDIQIKI DDAQLDLKGV SFWVTASVVT LFLAWSTFVV LFFSRVSALF FTFVIDKYLR
61: LSKNGIHFKI GGISISGLHA GKIMFRNVIY DNGDMTIKVN DGHLLFKYWK SVEHRHLNLS
121: TKRASRLHLV LNGLHVNIYN NLTKYTEIAR IRRFDWFFEN TNMNDARRPQ TKPPDTSPPS
181: SVWENMWNLL GIVHIEVSAG CILVGNKFLP YALWTRFENL NSKTSVTESA NDRALLTFEG
241: ETENVAVSLI KNEQFDFTAK DKDPPRTMGN DGCPLLQSAS LEFVYKQDLL GYVTDDEPQS
301: ITLKLPLWSS EWRFGNNTVL SYGPWAEQQR FLIYSFFYPP DFQNSTATAM PTRGKKRIHV
361: KHDVKIILTK ETCMDIWFMR GEQLESIRTR CGPLSSLDMS ILWITTEKGF YWNMKAEFLN
421: FEATTSLIFT KLFSCKKFNV DGSFVYPLTW NGEQTWTIDY AFTKANAWFV WDHKRLFTDL
481: INDWIGDDPS DISKFVPFRV HNRMKVVDGF EVIMLLNESN WVDTADMNAE NVEVAIVGEK
541: LSFECELPFV DFLPQTQMVK YEMRGEKSVA MRAKFPPDSA TAPIRAALSR LARCNSYAPP
601: SKHGTHSLDT DVWFELWRTE LVKMDFDHHY RPLIVKSNIP SDIPFSILSD YLPPPANHPW
661: DLEPDYLGVD ILIEGSDVKF TGLLVKLLFE LKNNYFGWYD SMTSVDDEKI DDPIKLKASF
721: DKTNANGMKP VEYFRTMNVD VTVRVCNVRA EMLLYSPAID EGAEPEKVPV VFVEEVAVEV
781: KKTKTQALIQ VGVSPACAYL DKSSQGSGPG CITLSGFQFR GHAMYSAKEV AWNMGLVEYG
841: WIMEILVGDI AGTLDFPAHA HVLHQIMESL LMFVISPDDA TKVPDRMQFC QHGQLIKACS
901: IAGKKTNEIL GPCKTEEQMK YRQIRISVDS VNLTFVEEKT ILQISADPVR VTICNAHESR
961: FTEHVCIRVP GISIRQAVRI KEKPENIWIE GANAAIEGVS LDIELPTPKS ASPTIGKERL
1021: EFVRMHDADT KRLHFLWADH SVWGCACFGN TCFFGDVDEI GSTFMETLTK KKFFVPGIER
1081: NPEKQPQVMQ SVILKNKPIL SNQPHMFYKK PKNADVVITI RKESTGDTES FHSARSQQSP
1141: GLRILQSMEM SSSYATFVDN VRVELPSAIT VPQFGEPGAI LEWCQAHQAT RIINDVNTSG
1201: VNEVRFLSKP KKSQDIEYNT SRDTLGKRRL AINGVAATSL DLFVTPIGIE AFERLVTAAS
1261: HSVPAINPCI LVHMCYRDCV LKKHRQPLTE SLFADEDNDS EPISEVDITV DLPRVSIGLF
1321: QCGVKKNIVK SNHTDHITAN MGLLLIDRAF IQSKLIPAES VSQDFSADTS NLSSTLYQLN
1381: GSAITVQLLQ LTNRDAPDFG SSGTATTPNN WEHCAISRRM NNLEPRVMMD FNVSDTLIIL
1441: ERRPIILLLP DKSTTAITPI HSPANAPTPT AMNRTPTLTL TPSAGAGGGE RAEPMRKKKK
1501: MICEHYLKAD IGSVTTALVM ARPQELTAGD EFPIYEALAP VMVSWLSVVE NFLRTVDKFI
1561: HTVECWKSVA MAKVLKLALD STDEKVVVKV GKNRMGRTRV LSAHQASCPS CILLKTLFRW
1621: FAYAGNAPGA INHRLDIRPE FEIEETRKTA LMALLSHWQS DVGKELKLVS YEDAHRFKVT
1681: RPDEAAIVAL TKSKRLKRKM LEKKESSKKE TRVVMEVKPE QPKAKRGRMS PAPLLKKLRK
1741: KAGDDDFDDD SMKFLSDVEM QEFNTLPLYE DYEDDEMLEN LDSEPKIDDK VDLYTWMRNA
1801: QRESTLRRRK LAGGAEGSVK DDLNLKGYIN PMDIQQKAYY YNIYRWAQLQ WTSLDGIEKD
1861: HWHLDYSVTL REVDVRMMAK SIKNSSDHLR QYITPAQQKV MQVRNAAVNG GMVWKMERDE
1921: RRKIPLHGQW NISYSGNVEG IRFLIGMATV SLGKELSLVL RVAMEAKNEL RMHSTAESTP
1981: RNEVKVFKPV VPNQYDLAVE WDEKVLDMTR DYEKHMQRMR TNKEDVVEKV KVMVNGSAMV
2041: SSIVLESVLN DLYVSVTISQ IVLAHSKNPM PDIPVVVHAV TLSTTPTAAA AEDKKTATLT
2101: KKSVSSTFKI DDLTVSLTKM KLTLSEADSS NKKSDILRCT LNSSSFNVHT NLKTLTSAKE
2161: SNRPKNNLIN SNIATTATLR LGALEGTMPM AAYSLHDVVM RHGKELEQQL NRLAAQPAST
2221: PLSSSTPFPS AEQSLLAKVA DMKTAPEPVV ITQAEFKPLT TLPATAAHVQ DAKGQIVRRV
2281: PVAVVSFSIE LTSIEMNIQL LPSLQAKYRI NRATSNGITG VQANWSILLD EHFFEFCVTG
2341: QGGKTETFRL QLPSVTSDGL YQAEQGVSSQ KPSTDKKLIY REGGSLQMTV VLGRVNHIFT
2401: TELLNQLMFA EHSFRTELTA LINRIRSSSF ASTNSSRSAQ STNDRVNSTA NLKLLLPVQT
2461: TSTPVHIEKP PLLFSIKIQT KEIPRKDEKT DKDAKTPKAS GASGNLDQSQ HPSHSTHVKS
2521: TPWLQLTAAT PTQTAVRLTV DSLEGELTNK WVVKEEGSKE RIYGNAVIHF NAKLGQLIKP
2581: VPTGDSVAAT DVTDLQEFAT FMTQVRVENK ERNMFNSSYS YHISLNRPIF LVKAAAIDKA
2641: ILLWLNYKNT YDYWRNEREK VVQEKTTTKL SNAGMFSPTQ IAEDADMNLS LAINNGMYMC
2701: MPLYSHDVTE GMPALVLSLQ KSNLSVLVKK ELTCKASFNG FKCSFVDDFD EQALTQSFLD
2761: ATHSDQSNCI FFPEGTYQLC SKAEATKGPA KWVLSVSAEM QGVEIDLDTR IGKLAKLLVN
2821: TFSMIRTDDD DDMSFWGDEG ELDSDEEKVE GASELKKLKA EEKVPWMENK MHEHSRAVFE
2881: LAARGVSNKL IEAEKHKLRQ YELIRFKAFR RNVVEKLKKG TTASRQHTET PPPQPRPDTT
2941: SRRNSRTTST SQKNSEDLTT PGDIETVNFN LDVKVNITSG TCTLRTQKKE GANQLALPGI
3001: LKRLNLGTKD IKAMFEPQII TTTTFSIPSV EIKAYHVSDP SNRSTDEFCK DKREKISKGL
3061: AKDADKLHRD LHNKSRFGNT YINGGGGPKT STVPPPPKRG CFYIFVGLAS MPSETVVTPH
3121: LATYFEQVLE PLPPSAVFQS QNNTREASVP DDGKGDANNE VHNIMAMDTA AFPIDFVFYL
3181: DVQSSTIRFD GKQPTSRSQT QADCLLTLPR LTLELTSKRT RDNIDNYVGG IHISGQFKGF
3241: MLKIYNPLEL EPDSSRALQL SLDLLSFVIS RNKNSSTEPD NRVRFVFSSQ ISKASFEYNF
3301: RRLGELIQFP KPWYRAAIAR RVFFGDQAAP RQKDDASDIT GTTRSRLPTD PKSLQPPAAS
3361: TASTGSGSFV PHQRKPWTAL VLAAIQWNEF EVTAFMSNTM GKTTWKATKG LVWGDAKLNS
3421: LNERDVSISF VLGSSELCAR DGAISGTIML NNLKVSADHS LSADVKRVPV NKAKIRLEWI
3481: TANIEWMSRR VLIAKWCGPS FKVNDYYKGL KEGDHFALSE LGMNVQASWK DLQVVITKST
3541: VDDVAAIVNR LISFIDEQLK NSRILLGNLS ASTNLKKQAQ ALIESRKPTT HFWEKVLDYM
3601: SEMQMNEQLM GLMEREGAKV GGHIELKAGG ISLVMMKGDM NADTWAVFHL RDACILFDPE
3661: ARMDFLDNSS QQKIGILLKQ TFCLQLGSRH GNQTENRANV CRVQTRFNNS RHLQKAEDIL
3721: EFFIGDVMKI IGSADHSEKK KLKEVEVIQS PISENENTAK SPTSTFSRFR SPGTSKTKES
3781: GPATNHNVME LFQFPGLEAK MSSQQLNGVD DGDKYESVFQ MPMDVLTTFV CDFFSEVAIE
3841: TNFNAQVSFL PELLKSYLKE SHSGTSSSHS TNSSPAVSSS KESVVSETSK DPRIFTCQEW
3901: KVEPRVRFID RIKWTPPVLD DILKKLQIFD HRNTIPKVIQ RAVLDPLDAT LAASVIATLQ
3961: IVDNKKTIQK FKKSRTDSMA PTPKRRDSRR SSEEVSVSID IPDIITDISD ASFRPKHN