8.A.61.1.10
Cornichon 3, CHIH3, CNIH-3 or gamma8 regulatory protein, of 160 aas and 3 or 4 TMSs. It regulates the trafficking and gating properties of
AMPA-selective glutamate receptors (AMPARs) and promotes their targeting
to the cell membrane and synapses while modulating their gating properties
by regulating their rates of activation, deactivation and
desensitization (Shi et al. 2010). Structures of an AMPA receptor in complex with its auxiliary subunit, cornichon 3, has been determined (Nakagawa 2019). Inhibition of AMPA receptors (AMPARs, TC# 1.A.10.1.1) containing transmembrane AMPAR regulatory protein gamma-8 (TC# 8.A.61.1.10) with JNJ-55511118 (TC#8.A.179.1.1) shows preclinical efficacy in reducing chronic repetitive alcohol self-administration (Hoffman et al. 2021).
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| Accession Number: | Q8TBE1 |
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| Protein Name: | Protein cornichon homolog 3 |
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| Length: | 160 |
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| Molecular Weight: | 18976.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Cell junction1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MAFTFAAFCY MLSLVLCAAL IFFAIWHIIA FDELRTDFKS PIDQCNPVHA RERLRNIERI
61: CFLLRKLVLP EYSIHSLFCI MFLCAQEWLT LGLNVPLLFY HFWRYFHCPA DSSELAYDPP
121: VVMNADTLSY CQKEAWCKLA FYLLSFFYYL YCMIYTLVSS