8.A.61.1.8
Cornichon family AMPA receptor auxiliary protein 2 of 160 aas and 3 TMSs, CNIH-2 or CNIG2. It regulates the trafficking and gating
properties of AMPA-selective glutamate receptors (AMPARs), and promotes
their targeting to the cell membrane and synapses. It also modulates their
gating properties by regulating their rates of activation, deactivation
and desensitization (Shi et al. 2010; Kato and Witkin 2018). Surface expression of functional AMPARs is enhanced by CNIH-2 to a greater extent than TARP gamma-2, suggesting that this distinction aids in maturation and membrane expression (Certain et al. 2023).
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| Accession Number: | Q6PI25 |
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| Protein Name: | Protein cornichon homolog 2 |
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| Length: | 160 |
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| Molecular Weight: | 18931.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MAFTFAAFCY MLTLVLCASL IFFVIWHIIA FDELRTDFKN PIDQGNPARA RERLKNIERI
61: CCLLRKLVVP EYSIHGLFCL MFLCAAEWVT LGLNIPLLFY HLWRYFHRPA DGSEVMYDAV
121: SIMNADILNY CQKESWCKLA FYLLSFFYYL YSMVYTLVSF