8.A.62.1.1 Tmub1 or HOPS of 246 aas and 3 TMSs in a 1 (N-terminal) + 2 (C-terminal) TMS arrangement (Yang et al. 2008). It functions in a complex with BORC (196 aas; Q969J3) and ARL8 (179 aas; Q96KC2), functioning in cholesterol egress from lysosomes (Anderson et al. 2022; see also TC# 2.A.6.6.1.1).
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Accession Number: | Q9BVT8 |
Protein Name: | Transmembrane and ubiquitin-like domain-containing protein 1 |
Length: | 246 |
Molecular Weight: | 26261.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 3 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
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1: MTLIEGVGDE VTVLFSVLAC LLVLALAWVS THTAEGGDPL PQPSGTPTPS QPSAAMAATD
61: SMRGEAPGAE TPSLRHRGQA AQPEPSTGFT ATPPAPDSPQ EPLVLRLKFL NDSEQVARAW
121: PHDTIGSLKR TQFPGREQQV RLIYQGQLLG DDTQTLGSLH LPPNCVLHCH VSTRVGPPNP
181: PCPPGSEPGP SGLEIGSLLL PLLLLLLLLL WYCQIQYRPF FPLTATLGLA GFTLLLSLLA
241: FAMYRP