8.A.64.1.1
PIRT (phosphoinositide-interacting protein) of 137 aas and 2 TMSs. Regulates Trp-CC channels (TC# 1.A.4) (Tang et al. 2015) including TRPM8 (Hilton et al. 2018). PIRT also regulates the ATP-activated P2X3 channel (TC# 1.A.7.1.6) in bladder cells (Gao et al. 2015). Calmodulin binds to the PIRT C-terminal alpha-helix, and a
cholesterol-recognition amino acid consensus (CRAC) domain in the outer
leaflet of the first transmembrane helix of PIRT binds to a number of
cholesterol-derivatives including cholecalciferol and oxytocin, which
explains the role of PIRT in regulating various ion channels (Sisco et al. 2020).
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| Accession Number: | P0C851 |
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| Protein Name: | Phosphoinositide-interacting protein |
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| Length: | 137 |
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| Molecular Weight: | 15334.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MTMETLPKVL EVDEKSPEAK DLLPSQTASS LCISSRSESV WTTTPRSNWE IYRKPIVIMS
61: VGGAILLFGV VITCLAYTLK LSDKSLSILK MVGPGFLSLG LMMLVCGLVW VPIIKKKQKH
121: RQKSNFLRSL KSFFLTR