8.A.64.1.8
Transmembrane protein 100, TMEM100 of 134 aas and 2 TMSs. It plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. It is also involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. It is expressed together with these two TRP channel proteins in odontoblasts (Liu et al. 2021). Upregulation of the DRG protein, TMEM100, facilitates dry-skin-induced pruritus by enhancing TRPA1 channel function (Pan et al. 2022).