8.A.65.1.1
The ER-PM junctional competence regulator, TMEM110 or STIMATE of 294 aas and 5-6 TMSs (Quintana et al. 2015). STIMATE (STIM-activating enhancer, encoded by
TMEM110 gene) is a positive regulator of Ca2+ influx in vertebrates. STIMATE physically interacts with
STIM1 to promote STIM1 conformational switch (Jing et al. 2015).
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| Accession Number: | Q86TL2 |
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| Protein Name: | Store-operated calcium entry regulator STIMATE |
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| Length: | 294 |
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| Molecular Weight: | 33187.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MQGPAGNASR GLPGGPPSTV ASGAGRCESG ALMHSFGIFL QGLLGVVAFS TLMLKRFREP
61: KHERRPWRIW FLDTSKQAIG MLFIHFANVY LADLTEEDPC SLYLINFLLD ATVGMLLIYV
121: GVRAVSVLVE WQQWESLRFG EYGDPLQCGA WVGQCALYIV IMIFEKSVVF IVLLILQWKK
181: VALLNPIENP DLKLAIVMLI VPFFVNALMF WVVDNFLMRK GKTKAKLEER GANQDSRNGS
241: KVRYRRAASH EESESEILIS ADDEMEESDV EEDLRRLTPL KPVKKKKHRF GLPV