8.A.74.1.4
Tomoregulin-1 or transmembrane protein with EGF-like and two follistatin-like domains 1 (TMEFF1) of 270 aas and 2 TMSs, one N-terminal and the other C-terminal. It may inhibit NODAL and BMP signaling during neural patterning, and may also be a tumor suppressor in brain cancers (Gery et al. 2003). It may modulate ion channel transport and glucose metabolism (Hudlikar et al. 2021).
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| Accession Number: | Q8IYR6 |
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| Protein Name: | Tomoregulin-1 |
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| Length: | 380 |
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| Molecular Weight: | 40934.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MGAAAAEAPL RLPAAPPLAF CCYTSVLLLF AFSLPGSRAS NQPPGGGGGS GGDCPGGKGK
61: SINCSELNVR ESDVRVCDES SCKYGGVCKE DGDGLKCACQ FQCHTNYIPV CGSNGDTYQN
121: ECFLRRAACK HQKEITVIAR GPCYSDNGSG SGEGEEEGSG AEVHRKHSKC GPCKYKAECD
181: EDAENVGCVC NIDCSGYSFN PVCASDGSSY NNPCFVREAS CIKQEQIDIR HLGHCTDTDD
241: TSLLGKKDDG LQYRPDVKDA SDQREDVYIG NHMPCPENLN GYCIHGKCEF IYSTQKASCR
301: CESGYTGQHC EKTDFSILYV VPSRQKLTHV LIAAIIGAVQ IAIIVAIVMC ITRKCPKNNR
361: GRRQKQNLGH FTSDTSSRMV