8.A.75.1.4
Transmembrane 4 L6 family member 20, TM4SF20, of 229 aas and 4 TMSs in a 3 + 1 TMS arrangement. Ceramide regulates TM4SF20 through topological inversion by altering the direction through which the protein is translocated across membranes during translation. This regulatory mechanism, denoted regulated alternative translocation, depends on a GXXXN motif present in the first TMS of TM4SF20, and residues important for this inversion have been identified (Wang et al. 2019; Ye 2020).
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| Accession Number: | Q53R12 |
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| Protein Name: | Transmembrane 4 L6 family member 20 |
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| Length: | 229 |
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| Molecular Weight: | 25075.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MTCCEGWTSC NGFSLLVLLL LGVVLNAIPL IVSLVEEDQF SQNPISCFEW WFPGIIGAGL
61: MAIPATTMSL TARKRACCNN RTGMFLSSLF SVITVIGALY CMLISIQALL KGPLMCNSPS
121: NSNANCEFSL KNISDIHPES FNLQWFFNDS CAPPTGFNKP TSNDTMASGW RASSFHFDSE
181: ENKHRLIHFS VFLGLLLVGI LEVLFGLSQI VIGFLGCLCG VSKRRSQIV