8.A.75.1.6
Transmembrane 4 L6 family member 1, TM4SF1 or TM4L6 family member 1 or CM3S1, of 202 aas and 4 TMSs in a 3 + 1 TMS arrangement. TM4SF1 is highly expressed in glioma tumor tissues and cell lines. The expression levels of TM4SF1 were negatively correlated with patients' survival rates. Silencing TM4SF1 by RNA interference inhibited the proliferation, migration, and invasion of glioma cells. Moreover, TM4SF1 silencing induced glioma cell cycle arrest and early apoptosis, while overexpression of TM4SF1 in glioma cells exhibited the opposite effects. Loss of TM4SF1 reduced phospho-ATK, Cyclin D1, Bcl-2, and MMP-9 levels in glioma cells. These findings provide novel insights into glioma pathogenesis (Zheng et al. 2022). The TM4SF1 encoding gene may be upregulated in uterine fibrosis (Cai et al. 2022). Six epithelial- mesenchymal transition-related genes, including TM4SF1, provide bioinformatic guidance to identify prognostic markers for idiopathic pulmonary fibrosis (Zhao et al. 2022). Reduction of MCT1 and its partner basigin are highly enriched in retinal glia and myelin-forming oligodendrocytes in optic nerves together with wolframin. Loss of MCT1 causes a failure in lactate transfer from glial to neuronal cell bodies and axons, leading to a chronic hypometabolic state in mice (Rossi et al. 2023).  A Tm4sf1-marked endothelial subpopulation is dysregulated in pulmonary arterial hypertension (Hong et al. 2023).

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