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8.A.8 The Phosphotransferase System HPr (HPr) Family

The HPr family consists of bacterial proteins, all of which function as phosphoryl transfer proteins. They are energy-coupling constituents of the phosphotransferase system (PTS) (TC #4.A.1-4.A.7) which catalyzes sugar uptake via a group translocation mechanism. HPr proteins are not known to be homologous to any non-PTS proteins. The E. coli genome encodes five HPr paralogues. The functions of several of these proteins are known. They function in PTS-related regulatory capacities.

References associated with 8.A.8 family:

Araki N., Suzuki T., Miyauchi K., Kasai D., Masai E. and Fukuda M. (201). Identification and characterization of uptake systems for glucose and fructose in Rhodococcus jostii RHA1. J Mol Microbiol Biotechnol. 20(3):125-36. 21464575
Parche, S., R. Schmid, and F. Titgemeyer. (1999). The phosphotransferase system (PTS) of Streptomyces coelicolor identification and biochemical analysis of a histidine phosphocarrier protein HPr encoded by the gene ptsH. Eur J Biochem 265: 308-317. 10491187
Pickl A., Johnsen U. and Schonheit P. (2012). Fructose degradation in the haloarchaeon Haloferax volcanii involves a bacterial type phosphoenolpyruvate-dependent phosphotransferase system, fructose-1-phosphate kinase, and class II fructose-1,6-bisphosphate aldolase. J Bacteriol. 194(12):3088-97. 22493022
Postma, P.W., J.W. Lengeler and G.R. Jacobson (1993). Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria. Microbiol. Rev. 57: 543-594. 8246840
Reizer, J., C. Hoischen, A. Reizer, T.N. Pham and M.H. Saier, Jr. (1993). Sequence analyses and evolutionary relationships among the energy-coupling proteins Enzyme I and HPr of the bacterial phosphoenolpyruvate:sugar phosphotransferase system. Prot. Sci. 2: 506-521. 7686067
Titgemeyer, F., J. Walkenhorst, J. Reizer, M.H. Stuiver, X. Cui, and M.H. Saier, Jr. (1995). Identification and characterization of phosphoenolpyruvate:fructose phosphotransferase systems in three Streptomyces species. Microbiology 141(Pt1): 51-58. 7894719