8.A.80.1.2
Vacuolar ATPase subunit (VHA-20), also called Pro)renin receptor, PRR, of 324 aas and 2 TMSs at the protein's N- and C-termini.  VHA-20 is indispensable for normal larval development, acidification of the intestine, and nutrient uptake. Inhibition of vha-20 by RNAi leads to complex deterioration of water and pH gradients at the level of the whole organism including distention of the pseudocoelome cavity. The prorenin receptor thus appears to play roles in the regulation of  body ion and water fluxes and in intestinal lumen acidification in nematodes (Zima et al. 2015).