8.A.83.1.2
Shisa8 protein of 492 aas and 2 TMSs with a Class
II PDZ domain. Regulates short term neuronal synaptic plasticity. Present in the olfactory bulb and cerebellum. Involved in prolongation of deactivation and an increase in
desensitization of GluA2 without change in that of GluA1. It slowed
recovery from desensitization, enhanced of glutamate potency, and reducted cyclothiazide potency (Kato and Witkin 2018).
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| Accession Number: | B8ZZ34 |
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| Protein Name: | Putative protein shisa-8 |
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| Length: | 492 |
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| Molecular Weight: | 51412.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MARAGARGLL GGRRPPGLRL ALALRLALLL ARPPSGRAGA PEAQGPAAPG TTAPEGGDRC
61: RGYYDVMGQW DPPFNCSSGA YSFCCGTCGY RFCCHDGPRR LDQSRCSNYD TPAWVQTGRP
121: PARARDTAAP RDPGRERSHT AVYAVCGVAA LLVLAGIGAR LGLERAHSPR ARRTVTRALT
181: ELLKQPGPQE PLPPTLGPPL GGCVQVQMGD GLPRGSPHNS AGPRTPRLAR ASPPGEPFMR
241: VAPPGLAAAA AARDSEPGPV PGAGGCGEDR LGSQPRPENG PPGSHRTASG RGLRRGDSEG
301: GVNRGIGPSR VSLLAPDKKR LNNAPRGSAA PGPPRGPRLQ GGGSLTLQPD YAKYATFKAA
361: ALKAAEAAPR DFCQRFPALE PSPRQPPARA PRPSPDLPAP LDACPWAPPV YAPPAAPGPY
421: AAWTSSRPAR PAPLSHPTAR AFQVPRRPGH AARRQFSVKM PETFNPQLPG LYGSAGRGSR
481: YLRTNSKTEV TV