8.A.83.1.3
Shisa9, or CKAMP44 of 424 aas and 2 TMSs. Regulator of short-term neuronal synaptic
plasticity in the dentate gyrus. It associates with AMPA receptors
(ionotropic glutamate receptors; TC#1/A/10) in synaptic spines and promotes AMPA
receptor desensitization at excitatory synapses. It is found in the dentate gyrus and olfactory bulb. It has a class II PDZ domain and is expressed in a majority of regions of the brain. It slows recovery from desensitization, enhances glutamate potency and reduces cyclothiazide potency and efficacy (Kato and Witkin 2018).
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| Accession Number: | B4DS77 |
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| Protein Name: | Protein shisa-9 |
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| Length: | 424 |
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| Molecular Weight: | 46925.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell projection1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MRRVLRLLLG CFLTELCARV CRAQERAGHG QLAQLGGVLL LAGGNRSGAA SGEASEGAEA
61: SDAPPTRAPT PDFCRGYFDV MGQWDPPFNC SSGDFIFCCG TCGFRFCCTF KKRRLNQSTC
121: TNYDTPLWLN TGKPPARKDD PLHDPTKDKT NLIVYIICGV VAVMVLVGIF TKLGLEKAHR
181: PQREHMSRAL ADVMRPQGHC NTDHMERDLN IVVHVQHYEN MDTRTPINNL HATQMNNAVP
241: TSPLLQQMGH PHSYPNLGQI SNPYEQQPPG KELNKYASLK AVGSSDGDWA VSTLKSPKAD
301: KVNDDFYTKR RHLAELAAKG NLPLHPVRVE DEPRAFSPEH GPAKQNGQKS RTNKMPPHPL
361: AYTSTTNFKG WDPNEQSLRR QAYSNKGKLG TAETGSSDPL GTRPQHYPPP QPYFITNSKT
421: EVTV