8.A.83.1.4
Shisa7 of 538 aas and 2 TMSs.  It is a AMPAR modulatory protein affecting channel kinetics of AMPARs, necessary for synaptic hippocampal plasticity and memory recall (Schmitz et al. 2017). Shisa7 controls receptor abundance at synapses and speeds up the channel deactivation kinetics. Shisa7 also potently enhances the action of diazepam, a classic benzodiazepine, on GABAARs. Genetic deletion of Shisa7 selectively impairs GABAergic transmission and diminishes the effects of diazepam in mice. Thus, Shisa7 regulates GABAAR trafficking, function, and pharmacology (Han et al. 2019). A kinetic basis for how Shisa7 modifies temporal attributes of GABAergic transmission at the single-channel level has been described (Castellano et al. 2022).