8.A.83.1.6
Shisa-2 (Shisa2) of 288 aas and 2 TMSs, an N-terminal targetting signal, and a central TMS, common to other Shisa proteins. It plays an essential role in the maturation of
presomitic mesoderm cells by individual attenuation of both Fgf and Wnt
signaling. It inhibits both Wnt and Fgf signaling through the regulation of
protein maturation and cell surface transport of their receptors
within the endoplasmic reticulum (Nagano et al. 2006).
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| Accession Number: | Q2WFL8 |
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| Protein Name: | Protein shisa-2 |
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| Length: | 288 |
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| Molecular Weight: | 31119.00 |
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| Species: | Xenopus laevis (African clawed frog) [8355] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MWLEGSPLAV LAAVSFLLSV LAAAQGSGEY CHGWLDAQAV WRDGFQCPER FDGDDSTICC
61: GKCELRYCCS SAEARLDQGV CNNDRQQGAP DHNRPDKDSP DSTAVPIYVP FLIVGSVFVA
121: FIIVGSLVAI CCCRCLRPKQ EPQQSRAPGS NRLMETIPMI SSASTSRGSS SRQSSTAASS
181: SSSANSGARP PPTRSQTNCC LPEGAMNNVY VNMPTNFSVL NCQQATQLVQ HQGQYLHPQF
241: VGYAVPHDSV PMTPVPQFID GLQGGYRQMQ SPYPHSNPEQ MMYPAVTV