8.A.84.1.4
TMEM59, isoform 1 of 324 aas and 1 or 2 TMSs. TMEM59 or Dendritic cell factor 1 (DCF1) modulates both O- and N-glycosylation of proteins as well as cell surface expression and secretion of the amyloid precursor protein (Ullrich et al. 2010). It also potentiates Wnt signaling by promoting signalosome formation (Gerlach et al. 2018). Finally, it is localized to mitochondria, endosomes, lysosomes, endoplasmic reticulum, and proteasome. It regulates neural stem cell differentiation and dendritic spine formation (Chen et al. 2018). A role for the TMEM59 gene in the hearing process, and mutations in this gene give rise to deafness (Mahfood et al. 2021).
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| Accession Number: | Q9BXS4 |
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| Protein Name: | Transmembrane protein 59 |
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| Length: | 323 |
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| Molecular Weight: | 36223.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Late endosome membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MAAPKGSLWV RTQLGLPPLL LLTMALAGGS GTASAEAFDS VLGDTASCHR ACQLTYPLHT
61: YPKEEELYAC QRGCRLFSIC QFVDDGIDLN RTKLECESAC TEAYSQSDEQ YACHLGCQNQ
121: LPFAELRQEQ LMSLMPKMHL LFPLTLVRSF WSDMMDSAQS FITSSWTFYL QADDGKIVIF
181: QSKPEIQYAP HLEQEPTNLR ESSLSKMSYL QMRNSQAHRN FLEDGESDGF LRCLSLNSGW
241: ILTTTLVLSV MVLLWICCAT VATAVEQYVP SEKLSIYGDL EFMNEQKLNR YPASSLVVVR
301: SKTEDHEEAG PLPTKVNLAH SEI