| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.85.1.1 | Heat-stable enterotoxin receptor, STAR, of 1073 aas and 2 or 3 TMSs, also called GUCY2C or GUC2C. It is the receptor for the E. coli heat-stable enterotoxin, STa. STAR is expressed primarily on intestinal epithelial cells and STa markedly stimulates the accumulation of cGMP in cells expressing guanyl cyclase-C which is also activated by the endogenous peptides guanylin and uroguanylin. Activation initiates salt and water movement in the intestine. STa, deregulates this pathway and causes secretory diarrhea. (Steinbrecher 2014). | Eukaryota |
Metazoa | STAR of Homo sapiens |
|
8.A.85.1.2 | Atrial natriurentic peptide receptor of 1047 aas, NPR2, ANPRB, of 1047 aas and probably 2 - 3 TMSs. Receptor for the C-type natriuretic peptide NPPC/CNP hormone. It has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Mutations cause dwarfism (Dickey et al. 2016). | Eukaryota |
Metazoa | NPR2 of Homo sapiens |
|
8.A.85.1.3 | Retinal guanylate cyclase 1, GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1, OF 1103 aas. Mutations cause autosomal dominant cone-rod dystrophy (Smith et al. 2007). | Eukaryota |
Metazoa | GC2D of Homo sapiens |
|
8.A.85.1.4 | Putative adenylate cyclase, CyaA, of 609 aas and 3 putative TMSs. | Bacteria |
Proteobacteria | CyaA of Bdellovibrio bacteriovorus |
|
8.A.85.1.5 | Putative adenylyl cyclase class-3/4/guanylyl cyclase of 500 aas and 4 TMSs near the N-terminus of the protein. | Bacteria |
Proteobacteria | Adenylyl cyclase of Marinobacter hydrocarbonoclasticus |
|
8.A.85.1.6 | Natriuretic peptide receptor 1, NPR1 or ANPRA, of 1061 aas and one N-terminal TMS. It is the receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. It has guanylate cyclase activity upon binding of the ligand (Koller et al. 1991). Natriuretic peptides relax human intrarenal arteries through natriuretic peptide receptor type-A recapitulated by soluble guanylyl cyclase agonists (Frees et al. 2020).
| Eukaryota |
Opisthokonta | NPR1 of Homo sapiens |
|
8.A.85.1.7 | Uncharacterized protein of 787 aas and 1 (N-terminus) + 1 (at residue 350) + 1 - 3 TMSs (at residues 400 - 470) followed by a hydrophilic domain that is homologous to other members of this family. The first 470 aas are not homologous to other members if this family. | Bacteria |
Proteobacteria | UP of Pelagibacteraceae bacterium TMED13 (marine metagenome) |
|
8.A.85.1.8 | Putative K+ channel, ACα, of 669 aas with two very hydrophobic putative TMSs following by 3 weakly hydrophone potential TMSs. | Eukaryota |
Sar | ACα of Plasmodium falciparum |
|
8.A.85.2.1 | Putative adenylate cyclase, CyaC of 483 aas and 6 - 8 TMSs with a 6 TMS N-terminal domain. | Bacteria |
Proteobacteria | CyaC of Bdellovibrio exovorus |
|
8.A.85.3.1 | Adenylate cyclase with N-terminal 6 TMS domain of 571 aas. | Bacteria |
Proteobacteria | Cya of Desulfobacterium autotrophicum |
|
8.A.85.3.2 | Metal-dependent phosphohydrolase of 428 aas and 6 N-terminal TMSs. | Bacteria |
Proteobacteria | Phosphohydrolase of Shewanella loihica |
|
8.A.85.3.3 | Uncharacterized HD domain-containing protein of 799 aas and 7 N-terminal TMSs. | Bacteria |
Firmicutes | UP of Butyrivibrio sp. CB08 |
|
8.A.85.9.5 | Uncharacterized membrane protein YgaE (UPF0421/DUF939 family) of 410 aas and 5 or 6 N-terminal TM | Bacteria |
Terrabacteria group | UP of Micromonospora echinospora |