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8.A.86.1.18
TM9SF4 of 642 aas and 10 TMSs in a 1 (N-terminal) + 9 (1 + 2 + 2 + 2 + 2 TMS) arrangement. TM9SF4 is present in normal and leukemic hematopoietic cells, and its marked expression occurs at the level of AMLs displaying granulocytic differentiation (Paolillo et al. 2015). It promotes autophagic flux under amino acid starvation (Sun et al. 2018).

Accession Number:Q92544
Protein Name:Transmembrane 9 superfamily member 4
Length:642
Molecular Weight:74519.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate copper cation, zinc ion

Cross database links:

Entrez Gene ID: 9777   
Pfam: PF02990   
KEGG: hsa:9777    hsa:9777   

Gene Ontology

GO:0016021 C:integral to membrane

References (8)

[1] “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.”  Nagase T.et.al.   9039502
[2] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Phosphoproteome of resting human platelets.”  Zahedi R.P.et.al.   18088087
[5] “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.”  Nagase T.et.al.   9039502
[6] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Phosphoproteome of resting human platelets.”  Zahedi R.P.et.al.   18088087

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MATAMDWLPW SLLLFSLMCE TSAFYVPGVA PINFHQNDPV EIKAVKLTSS RTQLPYEYYS 
61:	LPFCQPSKIT YKAENLGEVL RGDRIVNTPF QVLMNSEKKC EVLCSQSNKP VTLTVEQSRL 
121:	VAERITEDYY VHLIADNLPV ATRLELYSNR DSDDKKKEKD VQFEHGYRLG FTDVNKIYLH 
181:	NHLSFILYYH REDMEEDQEH TYRVVRFEVI PQSIRLEDLK ADEKSSCTLP EGTNSSPQEI 
241:	DPTKENQLYF TYSVHWEESD IKWASRWDTY LTMSDVQIHW FSIINSVVVV FFLSGILSMI 
301:	IIRTLRKDIA NYNKEDDIED TMEESGWKLV HGDVFRPPQY PMILSSLLGS GIQLFCMILI 
361:	VIFVAMLGML SPSSRGALMT TACFLFMFMG VFGGFSAGRL YRTLKGHRWK KGAFCTATLY 
421:	PGVVFGICFV LNCFIWGKHS SGAVPFPTMV ALLCMWFGIS LPLVYLGYYF GFRKQPYDNP 
481:	VRTNQIPRQI PEQRWYMNRF VGILMAGILP FGAMFIELFF IFSAIWENQF YYLFGFLFLV 
541:	FIILVVSCSQ ISIVMVYFQL CAEDYRWWWR NFLVSGGSAF YVLVYAIFYF VNKLDIVEFI 
601:	PSLLYFGYTA LMVLSFWLLT GTIGFYAAYM FVRKIYAAVK ID