8.A.87.2.1
TBC1 domain family member 5 of 795 aas and 2 or 3 putative TMSs. It may act as a GTPase-activating protein (GAP) for Rab family proteins and can displace RAB7A and the retromer CSC subcomplex from the endosomal membrane to the cytosol (Seaman et al. 2009; Harbour et al. 2010). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network and for regulation of autophagy (Popovic et al. 2012). It may act as a molecular switch between endosomal
and autophagosomal transport and is involved in reprogramming vesicle
trafficking upon autophagy induction (Popovic and Dikic 2014). Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling (Kvainickas et al. 2019).
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| Accession Number: | Q92609 |
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| Protein Name: | TBC1 domain family member 5 |
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| Length: | 795 |
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| Molecular Weight: | 89004.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Endosome membrane1 |
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| Substrate |
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1: MYHSLSETRH PLQPEEQEVG IDPLSSYSNK SGGDSNKNGR RTSSTLDSEG TFNSYRKEWE
61: ELFVNNNYLA TIRQKGINGQ LRSSRFRSIC WKLFLCVLPQ DKSQWISRIE ELRAWYSNIK
121: EIHITNPRKV VGQQDLMINN PLSQDEGSLW NKFFQDKELR SMIEQDVKRT FPEMQFFQQE
181: NVRKILTDVL FCYARENEQL LYKQGMHELL APIVFVLHCD HQAFLHASES AQPSEEMKTV
241: LNPEYLEHDA YAVFSQLMET AEPWFSTFEH DGQKGKETLM TPIPFARPQD LGPTIAIVTK
301: VNQIQDHLLK KHDIELYMHL NRLEIAPQIY GLRWVRLLFG REFPLQDLLV VWDALFADGL
361: SLGLVDYIFV AMLLYIRDAL ISSNYQTCLG LLMHYPFIGD VHSLILKALF LRDPKRNPRP
421: VTYQFHPNLD YYKARGADLM NKSRTNAKGA PLNINKVSNS LINFGRKLIS PAMAPGSAGG
481: PVPGGNSSSS SSVVIPTRTS AEAPSHHLQQ QQQQQRLMKS ESMPVQLNKG LSSKNISSSP
541: SVESLPGGRE FTGSPPSSAT KKDSFFSNIS RSRSHSKTMG RKESEEELEA QISFLQGQLN
601: DLDAMCKYCA KVMDTHLVNI QDVILQENLE KEDQILVSLA GLKQIKDILK GSLRFNQSQL
661: EAEENEQITI ADNHYCSSGQ GQGRGQGQSV QMSGAIKQAS SETPGCTDRG NSDDFILISK
721: DDDGSSARGS FSGQAQPLRT LRSTSGKSQA PVCSPLVFSD PLMGPASASS SNPSSSPDDD
781: SSKDSGFTIV SPLDI