8.A.87.3.1
Numb protein of 556 aas and 3 TMSs in a 1 + 2 TMS arrangement. It is required for determination of cell fate during sensory organ formation in embryos (Uemura et al. 1989). It restricts developmental potential and promotes maturation of
intermediary neuronal progenitor cells, probably acting as an
antagonist of Notch signaling (Janssens et al. 2014, Li et al. 2017). Increased phosphatidic acid derived from Phospholipase D action leads to defects in binary cell-fate decisions that are compatible with ectopic Notch activation in precursor cells. Null mutants of numb or the alpha-subunit of Adaptor Protein complex-2 enhances dominantly this phenotype (Medina-Yáñez et al. 2020).
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| Accession Number: | P16554 |
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| Protein Name: | Protein numb |
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| Length: | 556 |
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| Molecular Weight: | 60614.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Location1 / Topology2 / Orientation3: |
Nucleus1 |
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| Substrate |
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1: MGNSSSHTHE PLERGFTRGK FGDVKNGKSA SFRFSKKSPK KMDRLRRSFR DSFRRRKDRV
61: PESSKPHQWQ ADEEAVRSAT CSFSVKYLGC VEVFESRGMQ VCEEALKVLR QSRRRPVRGL
121: LHVSGDGLRV VDDETKGLIV DQTIEKVSFC APDRNHERGF SYICRDGTTR RWMCHGFLAC
181: KDSGERLSHA VGCAFAVCLE RKQRRDKECG VTMTFDTKNS TFTRTGSFRQ QTLTERLAMA
241: TVGTNERSVD GPGSAMPGPP AATVKPFNPF AIERPHATPN MLERQSSFRL STIGSQSPFK
301: RQMSLRINDL PSNADRQRAF LTAAAGNPMQ TPLRSVSPIA EVSPAKSAGA DPLSAAAVAA
361: DSVSQLCQEL SQGLSLLTQT DALLAAGEDL NFNNNRSINQ NIIAAEKQVQ HVHSYAPPTA
421: QVTPRVASTT PTYQTLHSQS PSRSEQSIET STELPNAEQW LGHVVRSTSP AAPKRPTYLA
481: NVGRAQTLAS GTGAAVGGGG PDDPFDAEWV ANVAAAKQLS PDLPIPSTAR SPLARHSTNP
541: FISPPKAPAQ SFQVQL