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8.A.88.1.1
Calciquestrin (CASQ) of 396 aas and 1 TMS. Calsequestrin is a high-capacity (~80 Ca2+ ions), moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Regulates the release of lumenal Ca2+ via the calcium release channel RYR1; thus playing a role in triggering muscle contraction (Sanchez et al. 2012).

Accession Number:P31415
Protein Name:Calsequestrin-1
Length:396
Molecular Weight:45160.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Sarcoplasmic reticulum1
Substrate

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Structure:
3UOM   5CRD   5CRE   5CRG   5CRH     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSATDRMGPR AVPGLRLALL LLLVLGTPKS GVQGQEGLDF PEYDGVDRVI NVNAKNYKNV 
61:	FKKYEVLALL YHEPPEDDKA SQRQFEMEEL ILELAAQVLE DKGVGFGLVD SEKDAAVAKK 
121:	LGLTEVDSMY VFKGDEVIEY DGEFSADTIV EFLLDVLEDP VELIEGEREL QAFENIEDEI 
181:	KLIGYFKSKD SEHYKAFEDA AEEFHPYIPF FATFDSKVAK KLTLKLNEID FYEAFMEEPV 
241:	TIPDKPNSEE EIVNFVEEHR RSTLRKLKPE SMYETWEDDM DGIHIVAFAE EADPDGFEFL 
301:	ETLKAVAQDN TENPDLSIIW IDPDDFPLLV PYWEKTFDID LSAPQIGVVN VTDADSVWME 
361:	MDDEEDLPSA EELEDWLEDV LEGEINTEDD DDDDDD