TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.88.2.5
Thioredoxin-related transmembrane protein 1, TMX1, TMX, TXNDC, TXNDC1, UNQ235/PRO268, of 280 aas and 2 - 4 TMSs, one N-terminal, one C-terminal, and possibly 1 or 2 inbetween (Guerra and Molinari 2020). The ER of mammals contains more than 20 members of the Protein Disulfide Isomerase (PDI) family. These enzymes regulate formation, isomerization and disassembly of covalent bonds between cysteine residues. As such, PDIs ensure protein folding, which is required to attain functional and transport-competent structure, and protein unfolding, which facilitates dislocation of defective gene products across the ER membrane for ER-associated degradation (ERAD). The PDI family includes over a dozen soluble members and few membrane-bound ones. Among the latter are five PDIs grouped in the thioredoxin-related transmembrane (TMX) protein family (Guerra and Molinari 2020).

Accession Number:Q9H3N1
Protein Name:Thioredoxin-related transmembrane protein 1
Length:280
Molecular Weight:31791.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate electron

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MAPSGSLAVP LAVLVLLLWG APWTHGRRSN VRVITDENWR ELLEGDWMIE FYAPWCPACQ 
61:	NLQPEWESFA EWGEDLEVNI AKVDVTEQPG LSGRFIITAL PTIYHCKDGE FRRYQGPRTK 
121:	KDFINFISDK EWKSIEPVSS WFGPGSVLMS SMSALFQLSM WIRTCHNYFI EDLGLPVWGS 
181:	YTVFALATLF SGLLLGLCMI FVADCLCPSK RRRPQPYPYP SKKLLSESAQ PLKKVEEEQE 
241:	ADEEDVSEEE AESKEGTNKD FPQNAIRQRS LGPSLATDKS