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8.A.88.2.6
Thioredoxin-related transmembrane protein 3 (TMX3) is essential to enable robust expression in Xenopus laevis oocytes of honeybee (Apis mellifera) and bumblebee (Bombus terrestris) as well as fruit fly (Drosophila melanogaster) nAChR heteromers targeted by neonicotinoids and not hitherto robustly expressed. This has enabled the characterization of picomolar target site actions of neonicotinoids, findings important in understanding their toxicity (Ihara et al. 2020).  

Accession Number:NP_648847.3
Protein Name:NP_648847.3 uncharacterized protein Dmel_CG5027 [Drosophila melanogaster]
Length:431
Molecular Weight:
Species:Drosophila melanogaster [7227]
Number of TMSs:1
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPNSMWIFG LISALLLTLG STGLSSKVLE LSDRFIDVRH EGQWLVMFYA PWCGYCKKTE 
61:	PIFALVAQAL HATNVRVGRL DCTKYPAAAK EFKVRGYPTI MFIKGNMEFT YNGDRGRDEL 
121:	VDYALRMSGP PVQLVTRTES VDMLKGSHTI FFIFVGQQEG VVWDTYYAAA EGYQEHGFFY 
181:	ATSEDIAAQH FDFEKLPAVI VYKEEQHHFY PHGHLAHEMD PNEVNETVFQ WVNVERFTLF 
241:	PKVTRFNIHQ LLKTNKYLVL AVVQEDKLNQ IATHELEFRD MVEGVIRKHR ARYHDKFQFG 
301:	WIGEPSIAHS IILDQLPTPH LIAINSSTQH HFIPEDDPMQ MTPQALHLFL ESIRNESAIA 
361:	YGGDTYFVRL NRALFEVRRA LRDMWLGNPV LTTVIFGLPL GFLSLIMYSI FCGDCLVTEE 
421:	DPDEDHEKKE