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| Accession Number: | Q07837 |
| Protein Name: | Neutral and basic amino acid transport protein rBAT |
| Length: | 685 |
| Molecular Weight: | 78852.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Single-pass type II membrane protein2 |
| Substrate | |
Cross database links:
| Entrez Gene ID: | 6519 |
|---|---|
| Pfam: | PF00128 |
| KEGG: | hsa:6519 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0005743
C:mitochondrial inner membrane
GO:0005774
C:vacuolar membrane
GO:0015174
F:basic amino acid transmembrane transporter activity
GO:0003824
F:catalytic activity
GO:0043169
F:cation binding
GO:0015184
F:L-cystine transmembrane transporter activity
GO:0005975
P:carbohydrate metabolic process
GO:0006520
P:cellular amino acid metabolic process
GO:0006811
P:ion transport
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References (18)[1] “Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport.” Lee W.-S.et.al. 8486766 [2] “Expression cloning of a human renal cDNA that induces high affinity transport of L-cystine shared with dibasic amino acids in Xenopus oocytes.” Bertran J.et.al. 7686906 [3] “Effects of truncation of the COOH-terminal region of a Na+-independent neutral and basic amino acid transporter on amino acid transport in Xenopus oocytes.” Miyamoto K.et.al. 8663184 [4] “Genomic organization of a human cystine transporter gene (SLC3A1) and identification of novel mutations causing cystinuria.” Endsley J.K.et.al. 9186880 [5] “Human cystinuria-related transporter: localization and functional characterization.” Mizoguchi K.et.al. 11318953 [6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [7] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [9] “Luminal heterodimeric amino acid transporter defective in cystinuria.” Pfeiffer R.et.al. 10588648 [10] “Genetic heterogeneity in cystinuria: the SLC3A1 gene is linked to type I but not to type III cystinuria.” Calonge M.J.et.al. 7568194 [11] “Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome.” Jaeken J.et.al. 16385448 [12] “Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine.” Calonge M.J.et.al. 8054986 [13] “Mutations in the SLC3A1 transporter gene in cystinuria.” Pras E.et.al. 7539209 [14] “Molecular genetics of cystinuria: identification of four new mutations and seven polymorphisms, and evidence for genetic heterogeneity.” Gasparini P.et.al. 7573036 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAEDKSKRDS IEMSMKGCQT NNGFVHNEDI LEQTPDPGSS TDNLKHSTRG ILGSQEPDFK 61: GVQPYAGMPK EVLFQFSGQA RYRIPREILF WLTVASVLVL IAATIAIIAL SPKCLDWWQE 121: GPMYQIYPRS FKDSNKDGNG DLKGIQDKLD YITALNIKTV WITSFYKSSL KDFRYGVEDF 181: REVDPIFGTM EDFENLVAAI HDKGLKLIID FIPNHTSDKH IWFQLSRTRT GKYTDYYIWH 241: DCTHENGKTI PPNNWLSVYG NSSWHFDEVR NQCYFHQFMK EQPDLNFRNP DVQEEIKEIL 301: RFWLTKGVDG FSLDAVKFLL EAKHLRDEIQ VNKTQIPDTV TQYSELYHDF TTTQVGMHDI 361: VRSFRQTMDQ YSTEPGRYRF MGTEAYAESI DRTVMYYGLP FIQEADFPFN NYLSMLDTVS 421: GNSVYEVITS WMENMPEGKW PNWMIGGPDS SRLTSRLGNQ YVNVMNMLLF TLPGTPITYY 481: GEEIGMGNIV AANLNESYDI NTLRSKSPMQ WDNSSNAGFS EASNTWLPTN SDYHTVNVDV 541: QKTQPRSALK LYQDLSLLHA NELLLNRGWF CHLRNDSHYV VYTRELDGID RIFIVVLNFG 601: ESTLLNLHNM ISGLPAKMRI RLSTNSADKG SKVDTSGIFL DKGEGLIFEH NTKNLLHRQT 661: AFRDRCFVSN RACYSSVLNI LYTSC