8.A.91.1.11
Syntaxin 17, Stx17, of 302 aas and 2 C-terminal TMSs. It is instrumental for engagement during autophagosome fusion with endolysosomes, and the process is regulated by kinase ULK1 and the apoptosis modulator BRUCE (Viret and Faure 2019). SNAREs localize on opposing membranes and assemble to
form a trans-SNARE complex, an extended, parallel four alpha-helical
bundle that drives membrane fusion (Cheng et al. 2017).
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| Accession Number: | P56962 |
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| Protein Name: | Syntaxin-17 |
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| Length: | 302 |
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| Molecular Weight: | 33403.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSEDEEKVKL RRLEPAIQKF IKIVIPTDLE RLRKHQINIE KYQRCRIWDK LHEEHINAGR
61: TVQQLRSNIR EIEKLCLKVR KDDLVLLKRM IDPVKEEASA ATAEFLQLHL ESVEELKKQF
121: NDEETLLQPP LTRSMTVGGA FHTTEAEASS QSLTQIYALP EIPQDQNAAE SWETLEADLI
181: ELSQLVTDFS LLVNSQQEKI DSIADHVNSA AVNVEEGTKN LGKAAKYKLA ALPVAGALIG
241: GMVGGPIGLL AGFKVAGIAA ALGGGVLGFT GGKLIQRKKQ KMMEKLTSSC PDLPSQTDKK
301: CS