8.A.91.1.12
Syntaxin 4, Stx4, of 297 aas and one C-terminal TMS. It is a plasma membrane t-SNARE that mediates docking of transport vesicles and is necessary for the translocation of SLC2A4 (glucose transporter; "Glut4, GTR4) from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, it may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and may play a role in docking of synaptic vesicles at presynaptic active zones. Lipid domains assemble syntaxin 4 within themselves by selectively interacting with the transmembrane domain of Stx4. The localized syntaxin 4, in turn, facilitated the fusion of transport vesicles that contained the dopamine transporter with the domain of the plasma membrane, which led to the localized distribution of the transporter to that domain. A pivotal role of a  phospholipase A1, specifically PLRP2, is played in the formation of functional domains in the plasma membrane of neurons (Kuge et al. 2020).