8.A.91.1.9
Syntaxin 5, Stx5, of 355 aas and one C-terminal TMS. It mediates ER to Golgi transport, and together with p115/USO1 and GM130/GOLGA2, is involved in vesicle tethering
and fusion at the cis-Golgi membrane to maintain the stacked and
inter-connected structure of the Golgi apparatus (Linders et al. 2019). Syntaxin 5 interacts with presenilin holoproteins and affects beta-amyloid peptide production (Suga et al. 2004).
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| Accession Number: | Q13190 |
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| Protein Name: | Syntaxin-5 |
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| Length: | 355 |
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| Molecular Weight: | 39673.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum-Golgi intermediate compartment membrane1 / Single-pass type IV membrane protein2 |
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| Substrate |
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1: MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AGSSSSDIAP LPPPVTLVPP PPDTMSCRDR
61: TQEFLSACKS LQTRQNGIQT NKPALRAVRQ RSEFTLMAKR IGKDLSNTFA KLEKLTILAK
121: RKSLFDDKAV EIEELTYIIK QDINSLNKQI AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ
181: SKLASMSNDF KSVLEVRTEN LKQQRSRREQ FSRAPVSALP LAPNHLGGGA VVLGAESHAS
241: KDVAIDMMDS RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET
301: IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF VVFLA