8.A.92.1.12
Katanin p80 WD40 hydrophilic repeat-containing subunit B1 homologue of 823 aas and 2 - 3 N-terminal TMSs plus 2-3 possible C-terminal TMSs. May participate in a complex which severs
microtubules in an ATP-dependent manner. Microtubule severing may
promote rapid reorganization of cellular microtubule arrays. This protein has at least 4 repeats of about 42 aas (WD40). The protein is an AAA ATPase which targets centrosomes (Hartman et al. 1998). p80 katanin is
targeted to spindle poles through a combination of direct microtubule
binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein (McNally et al. 2000).
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| Accession Number: | Q9FT96 |
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| Protein Name: | Katanin p80 WD40 repeat-containing subunit B1 homologue |
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| Length: | 823 |
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| Molecular Weight: | 90085.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MSDWGPVLVT VILFVMLTPG LLFQLPGRQK YVEFGNNDVY SKILFLNLHS FPIDLNLVSV
61: LRLAFWVLLK NLDGRRCKGF VSAMNTKRAY KLRILFSLIS SFREFVAHSA AVNCLKIGRK
121: SSRVLVTGGE DHKVNLWAIG KPNAILSLYG HSSGIDSVTF DASEGLVAAG AASGTIKLWD
181: LEEAKVVRTL TGHRSNCVSV NFHPFGEFFA SGSLDTNLKI WDIRKKGCIH TYKGHTRGVN
241: VLRFTPDGRW IVSGGEDNVV KVWDLTAGKL LHEFKSHEGK IQSLDFHPHE FLLATGSADK
301: TVKFWDLETF ELIGSGGTET TGVRCLTFNP DGKSVLCGLQ ESLKRTEPMS GGATQSNSHP
361: EKTSGSGRDQ AGLNDNSSKV ILGKLPGSQK VDPLLKETKS LGKLSVSQNS DPLPKDTKST
421: GRSSVSQSSD PLVKEPKPLG RFSATHSSDT VKESRTLSST GSVSDSPHRV TLTSAPKSAS
481: GISTVVPNAA ASKRNFGKAN PKANPPVVNK EDYFPVIVPR TEPIIEQASE SRAELDIIGR
541: TMPYSLQSKA ADSRRLSSSR NEPDLPTSSL LERSQSQPIE PITLQDGNTY PSDEGGSWDT
601: AERTNKESKC RVFGRFNSRS LGPVSSSSGG NMTAPNSRPS NMLKQRGNHV PVDQGITSAS
661: EEDIVADIMG QHDQFVSSMH SRLAKLQVVR RYWERNDIKN SISSIEKMAD NAVIADVLLI
721: VNERPEILTL DTCTSLLPLL TALLGSNMDS HLSVCLDLLL KLVRMYGSQI YSSLSAPSSV
781: GVDIEAEQRM ERYSCCFVEF EKIKACLPSL ARWVNFIYWT MKS